ArticleEnvironmental health perspectives2005
Prenatal dichlorodiphenyldichloroethylene (DDE) and asthma in children.
Article in Environmental health perspectives, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- The association between children's exposure to pesticides and asthma, wheezing, and lower respiratory tract infections. A systematic review and meta-analysis.Frontiers in public health · 2024Pooled it
- Is pesticide exposure a cause of obstructive airways disease?European respiratory review : an official journal of the European Respiratory Society · 2014Pooled it
- Association between exposure to pesticides and allergic diseases in children and adolescents: a systematic review with meta-analysis.Jornal de pediatriaPooled it
- Review
- Prenatal Exposure to Emerging Pesticides and Childhood Allergy Risk: A Mixture Assessment in an Urban Birth Cohort.Environmental science & technology letters · 2025Article
- Article
- Exploring the link between the pediatric exposome, respiratory health, and executive function in children: a narrative review.Frontiers in public health · 2024Review
- Effect of Gestational Pesticide Exposure on the Child's Respiratory System: A Narrative Review.International journal of environmental research and public health · 2022Review
- Sex specific associations between in utero exposure to persistent organic pollutants and allergy-related outcomes in childhood: The Rhea Mother-Child Cohort (Crete, Greece).Journal of developmental origins of health and disease · 2022Article
- Relationship between Respiratory Morbidity and Environmental Exposure to Organochlorine Pesticides in Armenia.Journal of health & pollution · 2021Article
- Associations between prenatal exposure to DDT and DDE and allergy symptoms and diagnoses in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE), South Africa.Environmental research · 2020Article
- Body Burden of Dichlorodiphenyl Dichloroethene (DDE) and Childhood Pulmonary Function.International journal of environmental research and public health · 2017Article
- WHO/UNEP global surveys of PCDDs, PCDFs, PCBs and DDTs in human milk and benefit-risk evaluation of breastfeeding.Archives of toxicology · 2017Review
- Exposure toBioMed research international · 2016Article
- Environmental exposure to pesticides and respiratory health.European respiratory review : an official journal of the European Respiratory Society · 2015Review
- Association between lung function in adults and plasma DDT and DDE levels: results from the Canadian Health Measures Survey.Environmental health perspectives · 2015Article
- Maternal concentrations of persistent organochlorine pollutants and the risk of asthma in offspring: results from a prospective cohort with 20 years of follow-up.Environmental health perspectives · 2014Article
- Risk factors for non-atopic asthma/wheeze in children and adolescents: a systematic review.Emerging themes in epidemiology · 2014Review
- A long-term risk? Prenatal POPs exposure and asthma in young adults.Environmental health perspectives · 2014Article
- Population characteristics of young African women influencing prenatal exposure to DDT (Manhiça, Mozambique).Environmental science and pollution research international · 2013Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prevalence of asthma increases with increasing dichlorodiphenyldichloroethylene (DDE) levels. However, the effect of early-life exposure, the fundamental window of exposure, is unknown. We assessed the association between prenatal DDE and other organochlorine compounds, and atopy and asthma during infancy. All women presenting for antenatal care in Menorca (Spain) over 12 months starting in mid-1997 were invited to take part in a longitudinal study; 482 children were subsequently enrolled, and 468 (97.1%) provided complete outcome data up to the fourth year of study. Prenatal exposure of organochlorine compounds was measured in cord serum in 405 (83%) children. Asthma was defined on the basis of wheezing at 4 years of age, persistent wheezing, or doctor-diagnosed asthma. We measured specific immunoglobulin-E (IgE) against house dust mite, cat, and grass in sera extracted at 4 years of age. DDE (median = 1.03 ng/mL) was detected in all children, as well as hexachlorobenzene (0.68 ng/mL) and polychlorobiphenyls (0.69 ng/mL). Wheezing at 4 years of age increased with DDE concentration, particularly at the highest quartile [9% in the lowest quartile (< 0.57 ng/mL) vs. 19% in the highest quartile (1.90 ng/mL); relative risk = 2.63 (95% confidence interval 1.19-4.69), adjusting for maternal asthma, breast-feeding, education, social class, or other organochlorines]. The association was not modified by IgE sensitization and occurred with the same strength among nonatopic subjects and among those with persistent wheezing or diagnosed asthma. DDE was not associated with atopy alone. Prenatal exposure to DDE residues may contribute to development of asthma.
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