ArticleEnvironmental health perspectives2005
Discrimination of vanadium from zinc using gene profiling in human bronchial epithelial cells.
Article in Environmental health perspectives, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Hepatic zinc deficiency dampens the acute phase response in patients with alcohol-associated hepatitis.Frontiers in immunology · 2025Article
- Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data.BMC medical genomics · 2013Article
- Comparative gene responses to collected ambient particles in vitro: endothelial responses.Physiological genomics · 2011Article
- Predicting environmental chemical factors associated with disease-related gene expression data.BMC medical genomics · 2010Article
- Profiling of zinc-altered gene expression in human prostate normal vs. cancer cells: a time course study.The Journal of nutritional biochemistry · 2009Article
- Identification of genes associated with multiple cancers via integrative analysis.BMC genomics · 2009Article
- Fine ambient particles induce oxidative stress and metal binding genes in human alveolar macrophages.American journal of respiratory cell and molecular biology · 2009Article
- Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitis.Respiratory research · 2007Article
- Up-regulation of tissue factor in human pulmonary artery endothelial cells after ultrafine particle exposure.Environmental health perspectives · 2007Article
- Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression.Genome biology · 2007Article
- The distance-to-source trend in vanadium and arsenic exposures for residents living near a petrochemical complex.Journal of exposure science & environmental epidemiologyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We hypothesized that gene expression profiling may discriminate vanadium from zinc in human bronchial epithelial cells (HBECs). RNA from HBECs exposed to vehicle, V (50 microM), or Zn (50 microM) for 4 hr (n = 4 paired experiments) was hybridized to Affymetrix Hu133A chips. Using one-class t-test with p < 0.01, we identified 140 and 76 genes with treatment:control ratios > or = 2.0 or < or = 0.5 for V and Zn, respectively. We then categorized these genes into functional pathways and compared the number of genes in each pathway between V and Zn using Fisher's exact test. Three pathways regulating gene transcription, inflammatory response, and cell proliferation distinguished V from Zn. When genes in these three pathways were matched with the 163 genes flagged by the same statistical filtration for V:Zn ratios, 12 genes were identified. The hierarchical clustering analysis showed that these 12 genes discriminated V from Zn and consisted of two clusters. Cluster 1 genes (ZBTB1, PML, ZNF44, SIX1, BCL6, ZNF450) were down-regulated by V and involved in gene transcription, whereas cluster 2 genes (IL8, IL1A, PTGS2, DTR, TNFAIP3, CXCL3) were up-regulated and linked to inflammatory response and cell proliferation. Also, metallothionein 1 genes (MT1F, MT1G, MT1K) were up-regulated by Zn only. Thus, using microarray analysis, we identified a small set of genes that may be used as biomarkers for discriminating V from Zn. The novel genes and pathways identified by the microarray may help us understand the pathogenesis of health effects caused by environmental V and Zn exposure.
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