ArticleBMC genomics2005
The angiotensin-converting enzyme (ACE) gene family of Anopheles gambiae.
Article in BMC genomics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
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- Proteomic analyses of venom from a Spider Hawk,The journal of venomous animals and toxins including tropical diseases · 2023Article
- An update on angiotensin-converting enzyme 2 structure/functions, polymorphism, and duplicitous nature in the pathophysiology of coronavirus disease 2019: Implications for vascular and coagulation disease associated with severe acute respiratory syndrome coronavirus infection.Frontiers in microbiology · 2022Review
- Control of aging by the renin-angiotensin system: a review ofFrontiers in pharmacology · 2022Review
- ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV.Clinical science (London, England : 1979) · 2020Review
- The Plethora of Angiotensin-Converting Enzyme-Processed Peptides in Mouse Plasma.Analytical chemistry · 2019Article
- The toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiae.Scientific reports · 2017Article
- Genome-Wide Identification and Characterization of Carboxypeptidase Genes in Silkworm (Bombyx mori).International journal of molecular sciences · 2016Article
- ACE for all - a molecular perspective.Journal of cell communication and signaling · 2014Article
- Characterization of the Rel2-regulated transcriptome and proteome of Anopheles stephensi identifies new anti-Plasmodium factors.Insect biochemistry and molecular biology · 2014Article
- Identification and characterization of seminal fluid proteins in the Asian tiger mosquito, Aedes albopictus.PLoS neglected tropical diseases · 2014Article
- Article
- Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE.BMC genomics · 2007Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMembers of the M2 family of peptidases, related to mammalian angiotensin converting enzyme (ACE), play important roles in regulating a number of physiological processes. As more invertebrate genomes are sequenced, there is increasing evidence of a variety of M2 peptidase genes, even within a single species. The function of these ACE-like proteins is largely unknown. Sequencing of the A. gambiae genome has revealed a number of ACE-like genes but probable errors in the Ensembl annotation have left the number of ACE-like genes, and their structure, unclear.
resultsTBLASTN and sequence analysis of cDNAs revealed that the A. gambiae genome contains nine genes (AnoACE genes) which code for proteins with similarity to mammalian ACE. Eight of these genes code for putative single domain enzymes similar to other insect ACEs described so far. AnoACE9, however, has several features in common with mammalian somatic ACE such as a two domain structure and a hydrophobic C terminus. Four of the AnoACE genes (2, 3, 7 and 9) were shown to be expressed at a variety of developmental stages. Expression of AnoACE3, AnoACE7 and AnoACE9 is induced by a blood meal, with AnoACE7 showing the largest (approximately 10-fold) induction.
conclusionGenes coding for two-domain ACEs have arisen several times during the course of evolution suggesting a common selective advantage to having an ACE with two active-sites in tandem in a single protein. AnoACE7 belongs to a sub-group of insect ACEs which are likely to be membrane-bound and which have an unusual, conserved gene structure.
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