ArticleThe international journal of cardiovascular imaging
Clinical validation of the gated blood pool SPECT QBS processing software in congestive heart failure patients: correlation with MUGA, first-pass RNV and 2D-echocardiography.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- EANM/ESC guidelines for radionuclide imaging of cardiac function.European journal of nuclear medicine and molecular imaging · 2008Guideline
- Review
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- Advanced Imaging Modalities to Monitor for Cardiotoxicity.Current treatment options in oncology · 2019Review
- Comprehensive review on cardio-oncology: Role of multimodality imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Review
- Comparison of biventricular ejection fractions using cadmium-zinc-telluride SPECT and planar equilibrium radionuclide angiography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Nuclear imaging in detection and monitoring of cardiotoxicity.World journal of radiology · 2014Review
- Gated tomographic radionuclide angiography using cadmium-zinc-telluride detector gamma camera; comparison to traditional gamma cameras.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
- [68Ga]-albumin-PET in the monitoring of left ventricular function in murine models of ischemic and dilated cardiomyopathy: comparison with cardiac MRI.Molecular imaging and biology · 2013Article
- Positron emission tomography in the assessment of left ventricular function in healthy rats: a comparison of four imaging methods.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Article
- Left ventricular functional assessment in murine models of ischemic and dilated cardiomyopathy using [18 F]FDG-PET: comparison with cardiac MRI and monitoring erythropoietin therapy.EJNMMI research · 2012Article
- Utility of prechemotherapy echocardiographical assessment of cardiac abnormalities.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2011Article
- Evaluation of new data processing algorithms for planar gated ventriculography (MUGA).Journal of applied clinical medical physics · 2009Article
- SPECT radionuclide angiography: it is time for a consensus statement.European journal of nuclear medicine and molecular imaging · 2007Review
- Comparison of radionuclide ventriculography using SPECT and planar techniques in different cardiac conditions.European journal of nuclear medicine and molecular imaging · 2007Article
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9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLeft (LVEF) and right ventricular ejection fraction (RVEF) as well as LV regional wall motion at rest are valuable tools to monitor and tailor treatment of congestive heart failure (CHF) patients. Gated blood pool SPECT (GBPS) is under evaluation as an "all-in-one" technique, providing information on LVEF, RVEF, and wall motion derived from a single examination. Aim of the study was to evaluate a commercially available automated GBPS processing software for EF measurements and wall motion analysis in heart failure patients.
methodsThirty-two patients (12 female; mean age+/-SD: 53+/-13 years), suffering from dilated (63%), ischemic (25%) or hypertrophic (13%) cardiomyopathy, were studied. First-pass radionuclide ventriculography (FP-RNV), planar multigated radionuclide angiography (MUGA), and GBPS were performed at rest after in vivo labeling of red blood cells, and LVEF and RVEF was calculated with each method. Later on the same day LVEF was calculated by echocardiography. LV wall motion (summed motion score and wall motion index) was derived from GBPS and echocardiography using the standard 16-segment model.
resultsMean LVEF measured by GBPS, echocardiography, MUGA and FP-RNV was 33+/-13%, 37+/-15%, 41+/-14% and 45+/-13%, respectively. LVEF values calculated from GBPS showed moderate to good correlation with FP-RNV (r=0.61), MUGA (r=0.65) and ECHO (r=0.74; all p<0.01). Mean RVEF calculated by GBPS, FP-RNV and MUGA was 45+/-14%, 46+/-9% and 38+/-9%, respectively. RVEF values calculated from GBPS showed weak correlation with FP-RNV (r=0.33) and MUGA (r=0.26; all p=n.s.). Assessment of GBPS wall motion was qualitatively possible in all patients. The agreement between GBPS and ECHO was 82% (kappa=0.73). The wall motion index showed good correlation between both methods (r=0.88; p<0.001).
conclusionAn automated algorithm for LVEF calculation and wall motion analysis using GBPS is feasible for clinical routine diagnostic in CHF patients. The RVEF calculation method needs to be improved before routine clinical application can be recommended.
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