ArticleJournal of biomedical science2006
Solution structure of the X4 protein coded by the SARS related coronavirus reveals an immunoglobulin like fold and suggests a binding activity to integrin I domains.
Article in Journal of biomedical science, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Evaluation of SARS-CoV-2 ORF7a Deletions from COVID-19-Positive Individuals and Its Impact on Virus Spread in Cell Culture.Viruses · 2023Article
- SARS-CoV-2 accessory protein 7b forms homotetramers in detergent.Virology journal · 2022Article
- A bioinformatic approach of targeting SARS-CoV-2 replication by silencing a conserved alternative reserve of the orf8 gene using host miRNAs.Computers in biology and medicine · 2022Article
- Genome sequence diversity of SARS-CoV-2 obtained from clinical samples in Uzbekistan.PloS one · 2022Article
- A deletion in SARS-CoV-2 ORF7 identified in COVID-19 outbreak in Uruguay.Transboundary and emerging diseases · 2021Article
- Structural insight reveals SARS-CoV-2 ORF7a as an immunomodulating factor for human CD14iScience · 2021Article
- Understanding COVID-19 via comparative analysis of dark proteomes of SARS-CoV-2, human SARS and bat SARS-like coronaviruses.Cellular and molecular life sciences : CMLS · 2021Article
- Structural assessment of SARS-CoV2 accessory protein ORF7a predicts LFA-1 and Mac-1 binding potential.Bioscience reports · 2021Article
- Article
- Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2.Journal of translational medicine · 2021Article
- Characterization of the SARS-CoV-2 coronavirus X4-like accessory protein.The Egyptian journal of medical human genetics · 2021Article
- Genomics functional analysis and drug screening of SARS-CoV-2.Genes & diseases · 2020Article
- Article
- Novel Immunoglobulin Domain Proteins Provide Insights into Evolution and Pathogenesis Mechanisms of SARS-Related Coronaviruses.bioRxiv : the preprint server for biology · 2020Article
- Functional Pangenome Analysis Shows Key Features of E Protein Are Preserved in SARS and SARS-CoV-2.Frontiers in cellular and infection microbiology · 2020Article
- Accessory proteins of SARS-CoV and other coronaviruses.Antiviral research · 2014Review
- From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses.Antiviral research · 2013Review
- The 7a accessory protein of severe acute respiratory syndrome coronavirus acts as an RNA silencing suppressor.Journal of virology · 2010Article
- The role of epithelial integrin receptors in recognition of pulmonary pathogens.Journal of innate immunity · 2009Review
- The ORF7b protein of severe acute respiratory syndrome coronavirus (SARS-CoV) is expressed in virus-infected cells and incorporated into SARS-CoV particles.Journal of virology · 2007Article
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4 authors.
Funding
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Abstract
The SARS related Coronavirus genome contains a variety of novel accessory genes. One of these, called ORF7a or ORF8, code for a protein, known as 7a, U122 or X4. We set out to determine the three-dimensional structure of the soluble ectodomain of this type-I transmembrane protein by nuclear magnetic resonance spectroscopy. The fold of the protein is the first member of a further variation of the immunoglobulin like beta-sandwich fold. Because X4 does not reveal significant sequence homologies to proteins in the data bases, we carried out a structure based similarity search for proteins with known function. High structural similarity to Dl domains of ICAM-1 and ICAM-2, and common features in amino acid sequence between X4 and ICAM-1, suggest X4 to possess binding activity for the alpha(L) integrin I domain of LFA-1. Further, based on this structure based prediction, potential functions of X4 in virus replication and pathogenesis are discussed.
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