ArticleJournal of cancer research and clinical oncology2006
Elevated risk of colorectal cancer associated with the AA genotype of the cyclin D1 A870G polymorphism in an Indian population.
Article in Journal of cancer research and clinical oncology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 6 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 6 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Association betweenBioscience reports · 2018Pooled it
- The association between CCND1 G870A polymorphism and colorectal cancer risk: A meta-analysis.Medicine · 2017Pooled it
- The cyclin D1 (CCND1) G870A polymorphism and lung cancer susceptibility: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Cyclin D1 G870A polymorphism and risk of nasopharyngeal carcinoma: a meta-analysis.TheScientificWorldJournal · 2013Pooled it
- Pooled it
- Cyclin D1 G870A polymorphism and colorectal cancer susceptibility: a meta-analysis of 20 populations.International journal of colorectal disease · 2011Pooled it
- Upregulation of cyclin D1 can act as an independent prognostic marker for longer survival time in human nasopharyngeal carcinoma.Journal of clinical laboratory analysis · 2020Article
- Prognostic Significance of Cyclin D1 Over-expression in Colorectal Cancer: An Experience from Madinah, Saudi Arabia.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- CCND1 G870A polymorphism and colorectal cancer risk: An updated meta-analysis.Molecular and clinical oncology · 2016Article
- Investigation ofOncoTargets and therapy · 2016Article
- Polymorphisms of cell cycle regulator genesOncology letters · 2015Article
- The significant association of CCND1 genotypes with colorectal cancer in Taiwan.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Polymorphisms in DNA repair genes XRCC1, XRCC3 and XPD, and colorectal cancer risk: a case-control study in an Indian population.Journal of cancer research and clinical oncology · 2010Article
- Association of familial colorectal cancer with variants in the E-cadherin (CDH1) and cyclin D1 (CCND1) genes.International journal of colorectal disease · 2008Article
- Cyclin D1 A870G polymorphism in Brazilian colorectal cancer patients.Journal of gastrointestinal cancer · 2008Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate whether the common cyclin D1 (CCND1) A870G polymorphism is a risk factor for colorectal cancer (CRC) in an Indian population.
methodsIn this study, 301 newly diagnosed CRC patients and 291 healthy control subjects were genotyped by the PCR-RFLP method. Genotype frequencies were compared between cases and controls, and the association of genotypes with CRC was studied.
resultsThe CCND1 870 A allele was more frequently observed in CRC patients than controls (0.63 vs. 0.56, P=0.01), and after adjustment for age, sex, smoking habits, family history, family income and the consumption of meat, fish, vegetables and fruit, an increased risk was observed for the AA genotype compared to the GG+AG genotype (OR=1.56; 95% CI: 1.10-2.21). The increased risk were also found for colon (OR=1.96; 95% CI: 1.08-3.57) and rectal cancer (OR=1.51; 95% CI: 1.04-2.19). No correlation was observed between genotypes and age of diagnosis of CRC (49.9, 48.7 and 49.4 years for the GG, AG and AA genotypes, respectively; P=0.84). Multivariate analysis also revealed a stronger positive association with the AA genotype among patients with high meat intake (OR=2.67; 95% CI: 1.29-5.51), and particularly significant inverse associations with the GG+AG genotypes were also found for those with high vegetable consumption (OR=0.46; 95% CI: 0.27-0.79 of 2-3 servings/day, and OR=0.31; 95% CI: 0.18-0.53 for >3 servings/day) and fish intake (OR=0.48; 95% CI: 0.28-0.82).
conclusionThese data support the hypothesis that the CCND1 A870G polymorphism may increase the risk of CRC in our Indian population.
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