ArticleHistochemistry and cell biology2006
Morphology of VIP/nNOS-immunoreactive myenteric neurons in the human gut.
Article in Histochemistry and cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- TNBS colitis induces architectural changes and alpha-synuclein overexpression in mouse distal colon: A morphological study.Cell and tissue research · 2025Article
- Automated computational analysis reveals structural changes in the enteric nervous system of nNOS deficient mice.Scientific reports · 2021Article
- Classification of human enteric neurons.Histochemistry and cell biology · 2021Review
- Nitrergic and Substance P Immunoreactive Neurons in the Enteric Nervous System of the Bottlenose Dolphin (Animals : an open access journal from MDPI · 2021Article
- Characterization of putative interneurons in the myenteric plexus of human colon.Neurogastroenterology and motility · 2021Article
- Hyperglycaemia-Induced Downregulation in Expression of nNOS Intramural Neurons of the Small Intestine in the Pig.International journal of molecular sciences · 2019Article
- Comparison of inhibitory neuromuscular transmission in the Cynomolgus monkey IAS and rectum: special emphasis on differences in purinergic transmission.The Journal of physiology · 2018Article
- Enteric neurons of the esophagus: an immunohistochemical study using donated elderly cadavers.Surgical and radiologic anatomy : SRA · 2017Article
- Chagasic megacolon: enteric neurons and related structures.Histochemistry and cell biology · 2014Review
- Region-specific differences in the human myenteric plexus: an immunohistochemical study using donated elderly cadavers.International journal of colorectal disease · 2014Article
- Diabetic gastrointestinal motility disorders and the role of enteric nervous system: current status and future directions.Neurogastroenterology and motility · 2014Review
- What neurons hide behind calretinin immunoreactivity in the human gut?Histochemistry and cell biology · 2014Article
- Nerve supply to the internal anal sphincter differs from that to the distal rectum: an immunohistochemical study of cadavers.International journal of colorectal disease · 2014Article
- Parkinson's disease is not associated with gastrointestinal myenteric ganglion neuron loss.Acta neuropathologica · 2012Article
- Neurochemical characterization of zinc transporter 3-like immunoreactive (ZnT3(+)) neurons in the intramural ganglia of the porcine duodenum.Journal of molecular neuroscience : MN · 2012Article
- Preponderance of inhibitory versus excitatory intramuscular nerve fibres in human chagasic megacolon.International journal of colorectal disease · 2012Article
- Diabetes-related alterations in the enteric nervous system and its microenvironment.World journal of diabetes · 2012Article
- Neurochemical phenotypes of myenteric neurons in the rhesus monkey.The Journal of comparative neurology · 2011Article
- Development of enteric neuron diversity.Journal of cellular and molecular medicine · 2009Review
- Spiny versus stubby: 3D reconstruction of human myenteric (type I) neurons.Histochemistry and cell biology · 2009Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we characterized human myenteric neurons co-immunoreactive for neuronal nitric oxide synthase (nNOS) and vasoactive intestinal peptide (VIP) by their morphology and their proportion as related to the putative entire myenteric neuronal population. Nine wholemounts (small and large intestinal samples) from nine patients were triple-stained for VIP, neurofilaments (NF) and nNOS. Most neurons immunoreactive for all three markers displayed radially emanating, partly branching dendrites with spiny endings. These neurons were called spiny neurons. The spiny character of their dendrites was more pronounced in the small intestinal specimens and differed markedly from enkephalinergic stubby neurons described earlier. Exclusively in the duodenum, some neurons displayed prominent main dendrites with spiny side branches. Of the axons which could be followed from the ganglion of origin within primary strands of the myenteric plexus beyond the next ganglion (70 out of 140 traced neurons), 94.3% run anally and 5.7% orally. Very few neurons reactive for both VIP and nNOS could not be morphologically classified due to weak or absent NF-immunoreactivity. Another six wholemounts were triple-stained for VIP, nNOS and Hu proteins (HU). The proportion of VIP/nNOS-coreactive neurons in relation to the number of HU-reactive neurons was between 5.8 and 11.5% in the small and between 10.6 and 17.5% in the large intestinal specimens. We conclude that human myenteric spiny neurons co-immunoreactive for VIP and nNOS represent either inhibitory motor or descending interneurons.
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