ReviewRheumatology international2006
Current concepts in the pathophysiology of fibromyalgia: the potential role of oxidative stress and nitric oxide.
Review in Rheumatology international, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07519824 (The Role of Bioelements in Fibromyalgia), which is not on this map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Bioelements in Fibromyalgia: Disease Activity or Depression-Anxiety?
Who cites it
34 citing papers in PubMed, 120 citations in OpenAlex.
- Antioxidant supplementation reduces endometriosis-related pelvic pain in humans.Translational research : the journal of laboratory and clinical medicine · 2013Trial
- Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation.Redox report : communications in free radical research · 2013Trial
- Serum antioxidants and nitric oxide levels in fibromyalgia: a controlled study.Rheumatology international · 2009Trial
- Review
- Diet and Lifestyle Modifications for Fibromyalgia.Current rheumatology reviews · 2024Review
- Skin Bioimpedance Analysis to Determine Cellular Integrity by Phase Angle in Women with Fibromyalgia: A Cross-Sectional Study.Biomedicines · 2023Article
- Assessment of the therapeutic potential of lutein and beta-carotene nanodispersions in a rat model of fibromyalgia.Scientific reports · 2023Article
- The relationship between dietary total antioxidant capacity, clinical parameters, and oxidative stress in fibromyalgia syndrome: A novel point of view.Turkish journal of physical medicine and rehabilitation · 2022Article
- Evaluation of balance, fall risk, and related factors in patients with fibromyalgia syndrome.Turkish journal of physical medicine and rehabilitation · 2021Article
- Daphnetin, a natural coumarin averts reserpine-induced fibromyalgia in mice: modulation of MAO-A.Experimental brain research · 2021Article
- The Effects of Balneotherapy on Oxidant/Antioxidant Status in Patients With Fibromyalgia: An Observational Study.Archives of rheumatology · 2020Article
- Mitochondrial Imbalance as a New Approach to the Study of Fibromyalgia.Open access rheumatology : research and reviews · 2020Article
- Ambroxol for the treatment of fibromyalgia: science or fiction?Journal of pain research · 2017Article
- Fibromyalgia syndrome: metabolic and autophagic processes in intermittent cold stress mice.Pharmacology research & perspectives · 2016Article
- Increased Reactive Oxygen Species Formation and Oxidative Stress in Rheumatoid Arthritis.PloS one · 2016Article
- Article
- Effects of 12-week combined exercise therapy on oxidative stress in female fibromyalgia patients.Rheumatology international · 2014Article
- Serum prolidase enzyme activity and oxidative status in patients with fibromyalgia.Redox report : communications in free radical research · 2014Article
- Iodinated contrast media can induce long-lasting oxidative stress in hemodialysis patients.Yonsei medical journal · 2013Article
- Is inflammation a mitochondrial dysfunction-dependent event in fibromyalgia?Antioxidants & redox signaling · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibromyalgia (FM) is a common chronic pain syndrome with an unknown etiology. Recent years added new information to our understanding of FM pathophysiology. Researches on genetics, biogenic amines, neurotransmitters, hypothalamic-pituitary-adrenal axis hormones, oxidative stress, and mechanisms of pain modulation, central sensitization, and autonomic functions in FM revealed various abnormalities indicating that multiple factors and mechanisms are involved in the pathogenesis of FM. Oxidative stress and nitric oxide may play an important role in FM pathophysiology, however it is still not clear whether oxidative stress abnormalities documented in FM are the cause or the effect. This should encourage further researches evaluating the potential role of oxidative stress and nitric oxide in the pathophysiology of FM and the efficacy of antioxidant treatments (omega-3 and -6 fatty acids, vitamins and others) in double blind and placebo controlled trials. These future researches will enhance our understanding of the complex pathophysiology of this disorder.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.