ArticleEuropean journal of clinical pharmacology2005
Utilization of oral antihyperglycemic drugs over a 7-year period (1998-2004) in a Hungarian population and adherence to drug therapy.
Article in European journal of clinical pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 36 citations in OpenAlex.
- Cigarette smoking, obesity, physical activity, and alcohol use as predictors of chemoprevention adherence in the National Surgical Adjuvant Breast and Bowel Project P-1 Breast Cancer Prevention Trial.Cancer prevention research (Philadelphia, Pa.) · 2011Trial
- Measuring the impact of an educational intervention in rheumatoid arthritis: An open-label, randomized trial.Archives of rheumatology · 2022Article
- Delta T, a Useful Indicator for Pharmacy Dispensing Data to Monitor Medication Adherence.Pharmaceutics · 2022Article
- Estimated Thresholds of Minimum Necessary Adherence for Effective Treatment with Direct Oral Anticoagulants - A Retrospective Cohort Study in Health Insurance Claims Data.Patient preference and adherence · 2021Article
- A Systematic Review of Medication Adherence Thresholds Dependent of Clinical Outcomes.Frontiers in pharmacology · 2018Article
- Operationalization and validation of a novel method to calculate adherence to polypharmacy with refill data from the Australian pharmaceutical benefits scheme (PBS) database.Clinical epidemiology · 2018Article
- Utilization of oral antidiabetic medications in Taiwan following strategies to promote access to medicines for chronic diseases in community pharmacies.Journal of pharmaceutical policy and practice · 2015Article
- Low utilisation of diabetes medicines in Iran, despite their affordability (2000-2012): a time-series and benchmarking study.BMJ open · 2014Article
- A method for calculating adherence to polypharmacy from dispensing data records.International journal of clinical pharmacy · 2014Article
- How to use pharmacy claims data to measure patient nonadherence? The example of oral diabetics in therapy of type 2 diabetes mellitus.The European journal of health economics : HEPAC : health economics in prevention and care · 2013Article
- [Use of prescription drugs in Spain and Europe].Atencion primaria · 2012Review
- Discrepancies between prescribed and defined daily doses: a matter of patients or drug classes?European journal of clinical pharmacology · 2011Article
- Outcomes of adding second hypoglycemic drug after metformin monotherapy failure among type 2 diabetes in Hungary.Health and quality of life outcomes · 2008Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo describe the quantitative and qualitative changes in the utilization of oral antihyperglycemic drugs (OAHDs) between 1998 and 2004 and to analyze patients' adherence to OAHD therapy.
methodsWe conducted a retrospective analysis of the electronic database of the Hungarian National Health Fund Administration for the years 1998 through 2004. All 912,620 prescriptions for OAHDs dispensed for the 38,855 patients in Csongrád County (430,000 inhabitants) were retrieved and analyzed according to the ATC/DDD (World Health Organization) methodology. Nonadherence was set as medication possession ratio <80%.
resultsThe number of patients using OAHDs significantly increased (P<0.001); the yearly prevalence of 2.88% in 1998 increased to 4.32% in 2004. The overall consumption of OAHDs increased by 76%, from 20.85 defined daily doses per 1,000 inhabitants per day (DDD/TID) in 1998 to 36.83 DDD/TID in 2004. While in 1998 glibenclamide was the most often prescribed agent, received by 61.7% of patients, its share dropped to 16.1% in 2004, and metformin became the leading agent prescribed for 43.0% of patients. During the study period, the adherence rate varied between 47.9% and 49.2%. Women had a significantly better (P<0.001) adherence rate than men, 51.3% vs. 45.5%. The adherence rate peaked in patients between 60 and 79 years and was lowest in patients in their 30s.
conclusionsThe utilization pattern of OAHDs considerably changed, but there were no significant changes in patients' adherence. The significant increase in the utilization of OAHDs is not the result of increased adherence but of increased patient number.
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