ArticleEuropean journal of applied physiology2006
Blood flow does not limit skeletal muscle force production during incremental isometric contractions.
Article in European journal of applied physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Acute neuromuscular and metabolic responses to a novel low-load combined isometric and isotonic resistance training protocol.European journal of applied physiology · 2026Trial
- New Zealand blackcurrant extract has no effect on physiological and cardiovascular responses during low-intensity sustained intermittent isometric contractions in men.European journal of applied physiology · 2026Trial
- Trial
- Effects of Knee Joint Angle on Intramuscular Blood Flow and Muscle Deoxygenation During Fatiguing Isometric Contractions.Scandinavian journal of medicine & science in sports · 2026Article
- Simultaneous assessment of blood flow changes in femoral artery and skeletal muscle microvasculature using pulsed-wave and power Doppler ultrasonography.European journal of applied physiology · 2025Article
- Intramuscular blood flow and muscle oxygenation of the vastus lateralis response to intermittent incremental muscle contractions.Experimental physiology · 2025Article
- Effects of autoregulated and non-autoregulated blood flow restriction on vastus medialis oblique responses during low-load resistance exercise.Frontiers in sports and active living · 2025Article
- Postcontractile blood oxygenation level-dependent (BOLD) response in Duchenne muscular dystrophy.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- A thermodynamic function of glycogen in brain and muscle.Progress in neurobiology · 2020Article
- Influence of group III/IV muscle afferents on small muscle mass exercise performance: a bioenergetics perspective.The Journal of physiology · 2018Article
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- Bioenergetics and ATP Synthesis during Exercise: Role of Group III/IV Muscle Afferents.Medicine and science in sports and exercise · 2017Article
- Muscle fatigue: general understanding and treatment.Experimental & molecular medicine · 2017Review
- The brain behaves as a muscle?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
- Obesity-related differences in neuromuscular fatigue in adolescent girls.European journal of applied physiology · 2015Article
- Mechanical compression during repeated sustained isometric muscle contractions and hyperemic recovery in healthy young males.Journal of physiological anthropology · 2015Article
- Blood flow and muscle oxygenation during low, moderate, and maximal sustained isometric contractions.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Decreased muscle endurance associated with diabetic neuropathy may be attributed partially to neuromuscular transmission failure.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Effect of Lactate Accumulation during Exercise-induced Muscle Fatigue on the Sensorimotor Cortex.Journal of physical therapy science · 2013Article
- Physiological effects of the TASER C2 conducted energy weapon.Forensic science, medicine, and pathology · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
It has been suggested that a transient limitation in blood flow during intermittent muscular contractions can contribute to muscle fatigue, and that this limitation is greater as contraction intensity increases. We investigated skeletal muscle blood flow and fatigue in 13 healthy, untrained men (21-27 years) during 16 min of intermittent (4 s contract, 6 s relax) isometric dorsiflexor contractions. Contractions began at 10% of pre-exercise maximal voluntary contraction (MVC) force and increased by 10% every 2 min. Hyperemia (i.e., post-contraction blood flow, measured by venous occlusion plethysmography) and MVC were measured at the end of each stage. Muscle volume measures were obtained using magnetic resonance imaging. After 10 min of exercise, submaximal force and post-contraction hyperemia plateaued. MVC fell from 8 min of exercise onwards (p=0.004), and this onset of fatigue preceded the plateau in submaximal force and hyperemia. Despite a large range in dorsiflexor muscle size (66.3-176.4 cm(3)) and strength (112.5-421.8 N), neither muscle size nor strength were related to fatigue. The temporal dissociation between changes in blood flow and the onset of fatigue (fall of MVC) suggest that limited blood flow was not a factor in the impaired force production observed during intermittent isometric dorsiflexor contractions in healthy young men. Additionally, post-contraction hyperemia increased linearly with increasing contraction intensity, reflecting a match between blood flow and force production throughout the protocol that was independent of fatigue.
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Registered trials
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