ArticleBiophysical journal2006
A consistent model for thermal fluctuations and protein-induced deformations in lipid bilayers.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed.
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- Observation of E-cadherin adherens junction dynamics with metal-induced energy transfer imaging and spectroscopy.Communications biology · 2024Article
- Membrane free-energy landscapes derived from atomistic dynamics explain nonuniversal cholesterol-induced stiffening.PNAS nexus · 2023Article
- Membrane free-energy landscapes derived from atomistic dynamics explain nonuniversal cholesterol-induced stiffening.bioRxiv : the preprint server for biology · 2023Article
- Membrane-Mediated Interactions Between Protein Inclusions.Frontiers in molecular biosciences · 2021Review
- Anionic nanoparticle-induced perturbation to phospholipid membranes affects ion channel function.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Direct Derivation of Free Energies of Membrane Deformation and Other Solvent Density Variations From Enhanced Sampling Molecular Dynamics.Journal of computational chemistry · 2020Article
- Lipid flip-flop and desorption from supported lipid bilayers is independent of curvature.PloS one · 2020Article
- Article
- Simple differences in the protein-membrane attachment mechanism have functional consequences for surface mechanics.The Journal of chemical physics · 2019Article
- Area Compressibility Moduli of the Monolayer Leaflets of Asymmetric Bilayers from Simulations.Biophysical journal · 2019Article
- Boundary lipids of the nicotinic acetylcholine receptor: Spontaneous partitioning via coarse-grained molecular dynamics simulation.Biochimica et biophysica acta. Biomembranes · 2019Article
- Simulation Best Practices for Lipid Membranes [Article v1.0].Living journal of computational molecular science · 2019Article
- Entropic forces drive clustering and spatial localization of influenza A M2 during viral budding.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Interactions between lipids and proteins are critical for organization of plasma membrane-ordered domains in tobacco BY-2 cells.Journal of experimental botany · 2018Article
- Membrane stiffness is modified by integral membrane proteins.Soft matter · 2016Article
- Membrane remodeling and mechanics: Experiments and simulations of α-Synuclein.Biochimica et biophysica acta · 2016Review
- Continuum descriptions of membranes and their interaction with proteins: Towards chemically accurate models.Biochimica et biophysica acta · 2016Review
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2 authors.
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Abstract
We present an elastic Hamiltonian for membrane energetics that captures bilayer undulation and peristaltic deformations over all wavelengths, including the short wavelength protrusion regime. The model implies continuous functional forms for thermal undulation and peristaltic amplitudes as a function of wavelength and predicts previously overlooked relationships between these curves. Undulation and peristaltic spectra display excellent agreement with data from both atomistic and coarse-grained models over all simulated length scales. Additionally, the model accurately predicts the bilayer's response to a cylindrical protein inclusion as observed in coarse-grained simulation. This elastic response provides an explanation for gramicidin ion channel lifetime versus membrane thickness data that requires no fit constants. The physical parameters inherent to this picture may be expressed in terms of familiar material properties associated with lipid monolayers. Inclusion of a finite monolayer spontaneous curvature is essential to obtain fully consistent agreement between theory and the full range of available simulation/experimental data.
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