ArticleBiophysical journal2006
Model of calcium oscillations due to negative feedback in olfactory cilia.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 48 citations in OpenAlex.
- Analysis of dim-light responses in rod and cone photoreceptors with altered calcium kinetics.Journal of mathematical biology · 2023Article
- CaProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Mechanisms of regulation of olfactory transduction and adaptation in the olfactory cilium.PloS one · 2014Article
- Disruption of intracellular calcium regulation is integral to aminoglycoside-induced hair cell death.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Concordant chemical reaction networks.Mathematical biosciences · 2012Article
- A dynamical feedback model for adaptation in the olfactory transduction pathway.Biophysical journal · 2012Article
- System identification of Drosophila olfactory sensory neurons.Journal of computational neuroscience · 2011Article
- Quantitative analysis of cellular metabolic dissipative, self-organized structures.International journal of molecular sciences · 2010Review
- Modelling and sensitivity analysis of the reactions involving receptor, G-protein and effector in vertebrate olfactory receptor neurons.Journal of computational neuroscience · 2009Article
- Computational model of the insect pheromone transduction cascade.PLoS computational biology · 2009Article
- Article
- Identification of Cl(Ca) channel distributions in olfactory cilia.Mathematical methods in the applied sciences · 2008Article
- Fast adaptation in mouse olfactory sensory neurons does not require the activity of phosphodiesterase.The Journal of general physiology · 2006Article
- Minimal model of spiky oscillations in NF-kappaB signaling.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a mathematical model for calcium oscillations in the cilia of olfactory sensory neurons. The underlying mechanism is based on direct negative regulation of cyclic nucleotide-gated channels by calcium/calmodulin and does not require any autocatalysis such as calcium-induced calcium release. The model is in quantitative agreement with available experimental data, both with respect to oscillations and to fast adaptation. We give predictions for the ranges of parameters in which oscillations should be observable. Relevance of the model to calcium oscillations in other systems is discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.