ArticleSexually transmitted infections2005
Aetiology of sexually transmitted infections and response to syndromic treatment in southwest Uganda.
Article in Sexually transmitted infections, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Interventions for prevention and treatment of vulvovaginal candidiasis in women with HIV infection.The Cochrane database of systematic reviews · 2011Pooled it
- Etiology of genital ulcer disease and association with HIV infection in Malawi.Sexually transmitted diseases · 2013Trial
- Prevalence of HIV and associated sociobehavioral factors among men with urethral discharge syndrome attending public health facilities in Kampala, Uganda.BMC infectious diseases · 2026Article
- High Preventive Effect of G2-S16 Anionic Carbosilane Dendrimer against Sexually Transmitted HSV-2 Infection.Molecules (Basel, Switzerland) · 2020Review
- Article
- The Etiology of Vaginal Discharge Syndrome in Zimbabwe: Results from the Zimbabwe STI Etiology Study.Sexually transmitted diseases · 2018Article
- HIV infection in patients with sexually transmitted infections in Zimbabwe - Results from the Zimbabwe STI etiology study.PloS one · 2018Article
- Article
- Rush to judgment: the STI-treatment trials and HIV in sub-Saharan Africa.Journal of the International AIDS Society · 2015Article
- Evaluation of syndromic management of sexually transmitted infections within the Kisumu Incidence Cohort Study.International journal of STD & AIDS · 2014Article
- Spectrum of vaginal discharge in a tertiary care setting.Tropical parasitology · 2013Article
- Risk factors, healthcare-seeking and sexual behaviour among patients with genital ulcers in Zambia.BMC public health · 2012Article
- Genital ulceration does not increase HIV-1 shedding in cervical or vaginal secretions of women taking antiretroviral therapy.Sexually transmitted infections · 2011Article
- Increased risk of genital ulcer disease in women during the first month after initiating antiretroviral therapy.Journal of acquired immune deficiency syndromes (1999) · 2009Article
- Evaluation of multiplex real-time PCR for detection of Haemophilus ducreyi, Treponema pallidum, herpes simplex virus type 1 and 2 in the diagnosis of genital ulcer disease in the Rakai District, Uganda.Sexually transmitted infections · 2009Article
- Genital tract infections among HIV-infected pregnant women in Malawi, Tanzania and Zambia.International journal of STD & AIDS · 2008Article
- Reproductive health for refugees by refugees in Guinea II: sexually transmitted infections.Conflict and health · 2008Article
- An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection.Bulletin of the World Health Organization · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the aetiology of genital ulcers and discharges in rural south western Uganda and to assess response to syndromic treatment.
methodA longitudinal, prospective study using laboratory testing and questionnaires to evaluate 561 adult men and women presenting with clinically verified genital ulcers, urethral, or vaginal discharge at a general outpatient clinic and two health centres between December 1999 and July 2001.
resultsOne third of patients had genital ulcers and two thirds discharges. There was good response to treatment in 461/508 patients (90.7%). Herpes simplex virus type 2 was found in 95/217 (43.8%) genital ulcers. In 24.1% of ulcer cases there was also a genital discharge. HIV seropositivity was high in ulcer cases (63.2%), with significantly more HSV2 and secondary bacterial infection than in seronegative cases. Neisseria gonorrhoeae was found in 135/204 (66.2%) male genital discharges. Female genital discharges were mostly associated with bacterial vaginosis (36.1%), Trichomonas vaginalis (18.9%), and candidiasis (18.6%).
conclusionsThe aetiological pattern of STI syndromes reported will help inform revision of national STI guidelines. The importance of herpes simplex virus type 2, the variation in causes of genital ulcers according to HIV serostatus, the high frequency of multiple infections and secondary bacterial contamination of genital ulcers are notable. These results help explain the lack of effect of an STI intervention on HIV incidence in a recent trial in this area.
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Registered trials
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