ReviewSexually transmitted infections2005
Syphilis in adults.
Review in Sexually transmitted infections, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02257658 (Doxycycline Prophylaxis or Incentive Payments to Reduce Incident Syphilis Among HIV- Infected Men Who Have Sex With Men Who Continue to Engage in High Risk Sex), which is not on this map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Doxycycline Prophylaxis or Incentive Payments to Reduce Incident Syphilis Among HIV- Infected Men Who Have Sex With Men Who Continue to Engage in High Risk Sex: A Randomized, Controlled Pilot Study
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 148 citations in OpenAlex.
- Ignored and undervalued in public health: a systematic review of health state utility values associated with syphilis infection.Health and quality of life outcomes · 2024Pooled it
- Antibiotics for syphilis diagnosed during pregnancy.The Cochrane database of systematic reviews · 2001Pooled it
- Molecular and serological evidence of systemiciScience · 2026Article
- Seroprevalence of Syphilis Among Pregnant Women on Antenatal Care Service at Wereda 04 Health Center in Kolfe Keraniyo Subcity, Addis Ababa, Ethiopia: A Cross-Sectional Study.Health science reports · 2026Article
- Strengthening STD Screening Programs: Comprehensive Evaluation of High-Throughput Immunoassays for HIV and Syphilis Detection.Microorganisms · 2026Article
- The mediating role of coping strategies in the relationship between stigma and quality of life among syphilis patients.Scientific reports · 2026Article
- Secondary Syphilis With Isolated Ocular Syphilis and Superimposed Corneal Abrasion: A Case Report.Cureus · 2025Article
- The Return of an Old Foe: Syphilis Among Women.Clinical obstetrics and gynecology · 2025Review
- Atypical Presentation of Syphilis With a Superimposed Methicillin-Resistant Staphylococcus aureus Infection.Cureus · 2025Article
- Secondary syphilis presenting with alopecia and leukoderma in a stable HIV-positive patient in a resource-limited setting: a case report.AIDS research and therapy · 2024Article
- Case report: Successive ipsilateral and contralateral laryngeal nerve palsy as probable manifestation of neuroborreliosis.Heliyon · 2023Article
- Neurosyphilis-Induced Psychosis: A Unique Presentation of Syphilis With a Primary Psychiatric Manifestation.Cureus · 2023Article
- Review
- Quality of life, depressive symptoms, anxiety, and sexual function in mothers of neonates with congenital syphilis in the Northeast Brazil: A cohort study.Lancet regional health. Americas · 2022Article
- Neurosyphilis: a series of 178 cases at the 3rd-level hospital of Marrakesh (Morocco).European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- A Case Report of Secondary Syphilis with Eosinophilic Spongiosis in an Human Immunodeficiency Virus Patient.Annals of dermatology · 2021Article
- Prevalence of sexually transmitted infections among cervical cancer suspected women at University of Gondar Comprehensive Specialized Hospital, North-west Ethiopia.BMC infectious diseases · 2021Article
- Predictors of serological cure after penicillin therapy in HIV-negative patients with early syphilis in Shenzhen, China.PloS one · 2021Article
- Development of a novel magnetic particle-based agglutination immunoassay for anticardiolipin antibody detection in syphilis.Sexually transmitted infections · 2020Article
- Development of a syphilis serum bank to support research, development, and evaluation of syphilis diagnostic tests in the United States.Diagnostic microbiology and infectious disease · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Syphilis is a sexually transmitted disease with protean manifestations resulting from infection by Treponema pallidum. It is systemic early from the outset, the primary pathology being vasculitis. Acquired syphilis can be divided into primary, secondary, latent, and tertiary stages. The infection can also be transmitted vertically resulting in congenital syphilis, and occasionally by blood transfusion and non-sexual contact. Diagnosis is mainly by dark field microscopy in early syphilis and by serological tests. The management in the tropics depends on the diagnostic facilities available: in resource poor countries, primary syphilis is managed syndromically as for anogenital ulcer. The introduction of rapid "desktop" serological tests may simplify and promote widespread screening for syphilis. The mainstay of treatment is with long acting penicillin. Syphilis promotes the transmission of HIV and both infections can simulate and interact with each other. Treponemes may persist despite effective treatment and may have a role in reactivation in immunosuppressed patients. Partner notification, health education, and screening in high risk populations and pregnant women to prevent congenital syphilis are essential aspects in controlling the infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.