ArticleProceedings of the National Academy of Sciences of the United States of America2005
Comparison of the protein-unfolding pathways between mitochondrial protein import and atomic-force microscopy measurements.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 64 citations in OpenAlex.
- Single-molecule mechanostructural fingerprinting of nucleic acid conformations.Nucleic acids research · 2026Article
- The local mechanostructural properties of protein cargoes regulate nucleocytoplasmic transport.Nature physics · 2026Article
- Structural anisotropy results in mechano-directional transport of proteins across nuclear pores.Nature physics · 2024Article
- Understanding the role of mechanics in nucleocytoplasmic transport.APL bioengineering · 2022Article
- DsbA is a redox-switchable mechanical chaperone.Chemical science · 2021Article
- Free-energy landscapes of membrane co-translocational protein unfolding.Communications biology · 2020Article
- Role of the membrane potential in mitochondrial protein unfolding and import.Scientific reports · 2019Article
- Evaluating the Functional Pore Size of Chloroplast TOC and TIC Protein Translocons: Import of Folded Proteins.The Plant cell · 2018Article
- Cotranslocational processing of the protein substrate calmodulin by an AAA+ unfoldase occurs via unfolding and refolding intermediates.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Topologically knotted deubiquitinases exhibit unprecedented mechanostability to withstand the proteolysis by an AAA+ protease.Scientific reports · 2018Article
- Tom70 enhances mitochondrial preprotein import efficiency by binding to internal targeting sequences.The Journal of cell biology · 2018Article
- Towards the development of an enzyme replacement therapy for the metabolic disorder propionic acidemia.Molecular genetics and metabolism reports · 2016Article
- Periodic forces trigger knot untying during translocation of knotted proteins.Scientific reports · 2016Article
- Protein unfolding by biological unfoldases: insights from modeling.Biophysical journal · 2014Article
- Protein co-translocational unfolding depends on the direction of pulling.Nature communications · 2014Article
- Mechanical unfolding studies of protein molecules.Biophysics (Nagoya-shi, Japan) · 2012Review
- Common ground for protein translocation: access control for mitochondria and chloroplasts.Nature reviews. Molecular cell biology · 2011Review
- The approaches for manipulating mitochondrial proteome.Environmental and molecular mutagenesis · 2010Review
- Structural basis for unfolding pathway-dependent stability of proteins: vectorial unfolding versus global unfolding.Protein science : a publication of the Protein Society · 2010Article
- Roles of Tom70 in import of presequence-containing mitochondrial proteins.The Journal of biological chemistry · 2009Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many newly synthesized proteins have to become unfolded during translocation across biological membranes. We have analyzed the effects of various stabilization/destabilization mutations in the Ig-like module of the muscle protein titin upon its import from the N terminus or C terminus into mitochondria. The effects of mutations on the import of the titin module from the C terminus correlate well with those on forced mechanical unfolding in atomic-force microscopy (AFM) measurements. On the other hand, as long as turnover of the mitochondrial Hsp70 system is not rate-limiting for the import, import of the titin module from the N terminus is sensitive to mutations in the N-terminal region but not the ones in the C-terminal region that affect resistance to global unfolding in AFM experiments. We propose that the mitochondrial-import system can catalyze precursor-unfolding by reducing the stability of unfolding intermediates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.