ArticleJournal of controlled release : official journal of the Controlled Release Society2006
Novel oral insulin delivery systems based on complexation polymer hydrogels: single and multiple administration studies in type 1 and 2 diabetic rats.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 188 citations in OpenAlex.
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- Critical updates on oral insulin drug delivery systems for type 2 diabetes mellitus.Journal of nanobiotechnology · 2025Review
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- PEGylated insulin loaded complexation hydrogels for protected oral delivery.Journal of controlled release : official journal of the Controlled Release Society · 2023Article
- Influence of PEGDA Molecular Weight and Concentration on the In Vitro Release of the Model Protein BSA-FITC from Photo Crosslinked Systems.Pharmaceutics · 2023Article
- Advanced biomedical hydrogels: molecular architecture and its impact on medical applications.Regenerative biomaterials · 2021Review
- A nanoemulsion/micelles mixed nanosystem for the oral administration of hydrophobically modified insulin.Drug delivery and translational research · 2021Article
- Recent Advances in Smart Biomaterials for the Detection and Treatment of Autoimmune Diseases.Advanced functional materials · 2020Article
- Engineering Smart Targeting Nanovesicles and Their Combination with Hydrogels for Controlled Drug Delivery.Pharmaceutics · 2020Review
- Micro and nanoscale technologies in oral drug delivery.Advanced drug delivery reviews · 2020Review
- Quantifying the Value of Orally Delivered Biologic Therapies: A Cost-Effectiveness Analysis of Oral Semaglutide.Journal of pharmaceutical sciences · 2019Article
- Oral Administration of Salecan-Based Hydrogels for Controlled Insulin Delivery.Journal of agricultural and food chemistry · 2018Article
- Low Molecular Weight Chitosan-Insulin Complexes Solubilized in a Mixture of Self-Assembled Labrosol and Plurol Oleaque and Their Glucose Reduction Activity in Rats.Marine drugs · 2018Article
- Recent advances in hemophilia B therapy.Drug delivery and translational research · 2017Review
- Design of pH-Responsive Biomaterials to Enable the Oral Route of Hematological Factor IX.Annals of biomedical engineering · 2016Article
- Complexation Hydrogels as Oral Delivery Vehicles of Therapeutic Antibodies: An in Vitro and ex Vivo Evaluation of Antibody Stability and Bioactivity.Industrial & engineering chemistry research · 2015Article
- Stimulus-responsive hydrogels: Theory, modern advances, and applications.Materials science & engineering. R, Reports : a review journal · 2015Article
- Preparation of pH sensitive insulin-loaded nano hydrogels and evaluation of insulin releasing in different pH conditions.Molecular biology reports · 2014Article
- Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies.Nature reviews. Drug discovery · 2014Review
- Use of Cross-Linked Poly(ethylene glycol)-Based Hydrogels for Protein Crystallization.Crystal growth & design · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Insulin-loaded polymer microparticles (ILP) composed of crosslinked poly(methacrylic acid) and poly(ethylene glycol) are multi-functional carriers showing high insulin incorporation efficiency, a rapid insulin release in the intestine based on their pH-dependent complexation properties, enzyme-inhibiting effects and mucoadhesive characteristics. Thus, they are potential carriers for insulin delivery via an oral route. Recent studies suggest that the polymer composition and particle size of ILP strongly influenced insulin bioavailability. Therefore, the present study aimed at finding an optimal formulation and designing carriers for oral insulin delivery using in vivo experiments. Various types of ILPs were prepared and administered orally to healthy and type 1 and 2 diabetic rats. The most promising formulation was subsequently used for in vivo multiple oral administration studies using diabetic rats. The microparticles of diameters of <53 microm (SS-ILP) composed of a 1:1 molar ratio of methacrylic acid/ethylene glycol units showed the most pronounced hypoglycaemic effects following oral administration to healthy rats, achieving a 9.5% pharmacological availability compared to subcutaneous insulin injection. Their usefulness was also confirmed with both type 1 and 2 diabetic rat groups. In a multiple administration study, SS-ILP significantly suppressed the postprandial rise in blood glucose and showed continuous hypoglycaemic effects following 3 times/day oral administration to both diabetic rat groups in the presence of foods. These results indicate that the blood glucose levels of diabetic rats can be effectively controlled by oral SS-ILP administration, and thus SS-ILP would be a promising delivery carrier of insulin via the oral route.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.