Evidence map›Paper›PMID 16323046›Full record

ArticleThe protein journal2005

In silico identification and analysis of new Artemis/Artemis-like sequences from fungal and metazoan species.

Diego Bonatto, Martin Brendel, João Antonio Pêgas Henriques

Abstract read
PubMed Publisher
In one paragraph

Article in The protein journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. The multifunctional SNM1 gene family: not just nucleases.Future oncology (London, England) · 2010
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Diego BonattoDepartamento de Biofísica/Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9500, 91507-970, Porto Alegre, RS, Brazil.
Martin Brendel
João Antonio Pêgas Henriques
Universidade Federal do Rio Grande do Sul · BRUniversidade de Caxias do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Artemis Group comprises mammalian proteins with important functions in the repair of ionizing radiation-induced DNA double-strand breaks and in the cleavage of DNA hairpin extremities generated during V(D)J recombination. Little is known about the presence of Artemis/Artemis-like proteins in non-mammalian species. We have characterized new Artemis/Artemis-like sequences from the genomes of some fungi and from non-mammalian metazoan species. An in-depth phylogenetic analysis of these new Artemis/Artemis-like sequences showed that they form a distinct clade within the Pso2p/Snm1p A and B Groups. Hydrophobic cluster analysis and three-dimensional modeling allowed to map and to compare conserved regions in these Artemis/Artemis-like proteins. The results indicate that Artemis probably belongs to an ancient DNA recombination mechanism that diversified with the evolution of multi-cellular eukaryotic lineage.

Indexed as

Models, MolecularAmino Acid SequenceAnimalsCluster AnalysisComputational BiologyDNA-Binding ProteinsDNA DamageEndodeoxyribonucleasesEndonucleasesFungal ProteinsHumansNuclear ProteinsPhylogenyRecombination, GeneticSaccharomyces cerevisiae ProteinsDCLRE1C protein, humanDclre1c protein, mouseDNA-Binding ProteinsEndodeoxyribonucleasesEndonucleasesFungal ProteinsNuclear ProteinsPSO2 protein, S cerevisiaeSaccharomyces cerevisiae Proteins

Identifiers

PMID16323046
OpenAlexW2069721221

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.