ArticleParasitology research2006
Do genes from the cholesterol synthesis pathway exist and express in Giardia intestinalis?
Article in Parasitology research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Insights about the structure of farnesyl diphosphate synthase (FPPS) and the activity of bisphosphonates on the proliferation and ultrastructure of Leishmania and Giardia.Parasites & vectors · 2020Article
- Parasites and steroid hormones: corticosteroid and sex steroid synthesis, their role in the parasite physiology and development.Frontiers in neuroscience · 2015Review
- Lipid metabolism in Giardia: a post-genomic perspective.Parasitology · 2011Review
- A novel sterol desaturase-like protein promoting dealkylation of phytosterols in Tetrahymena thermophila.Eukaryotic cell · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Giardia intestinalis undergo biochemical and morphological changes to survive under extreme environmental conditions. One of these changes is encystation. The trophozoites colonizing the upper part of the small intestine differentiate into a cyst, the infective form of the parasite. In in vitro cultures, the formation of cysts is induced by the depletion of cholesterol. It was reported that Giardia cannot synthesize cholesterol de novo. However, through bioinformatic studies, we found the genes that codify for the enzymes in the cholesterol biosynthesis pathway. We were able to verify the existence and define the transcription of four genes in the trophozoite and in parasites subjected to the encystation and excystation processes.
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Registered trials
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