ArticleEvidence-based complementary and alternative medicine : eCAM2005
Modulation of radiation-induced disturbances of antioxidant defense systems by ginsan.
Article in Evidence-based complementary and alternative medicine : eCAM, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Effect of a session of intensive exercise with ginseng supplementation on histone H3 protein methylation of skeletal muscle of nonathlete men.Molecular genetics & genomic medicine · 2019Trial
- Mountain-cultivated ginseng protects against cognitive impairments in aged GPx-1 knockout mice via activation of Nrf2/ChAT/ERK signaling pathway.Journal of ginseng research · 2023Article
- Polysaccharides from Chinese herbs as natural weapons against colorectal cancer.Bioscience reports · 2023Review
- Radioprotection of deinococcal exopolysaccharide BRD125 by regenerating hematopoietic stem cells.Frontiers in oncology · 2022Article
- Natural Food Polysaccharides Ameliorate Inflammatory Bowel Disease and Its Mechanisms.Foods (Basel, Switzerland) · 2021Review
- The structures and biological functions of polysaccharides from traditional Chinese herbs.Progress in molecular biology and translational science · 2019Review
- Effects of gamma rays on rat testis tissue according to the morphological parameters and immunohistochemistry: radioprotective role of silymarin.Electronic physician · 2017Article
- Podophyllotoxin and Rutin Modulates Ionizing Radiation-Induced Oxidative Stress and Apoptotic Cell Death in Mice Bone Marrow and Spleen.Frontiers in immunology · 2017Article
- Vaccination with Astragalus and Ginseng Polysaccharides Improves Immune Response of Chickens against H5N1 Avian Influenza Virus.BioMed research international · 2016Article
- Protective effect of ginseng against gamma-irradiation-induced oxidative stress and endothelial dysfunction in rats.EXCLI journal · 2013Article
- Article
- Effects of ginseng and echinacea on cytokine mRNA expression in rats.TheScientificWorldJournal · 2012Article
- Protective effects of selenocystine against γ-radiation-induced genotoxicity in Swiss albino mice.Radiation and environmental biophysics · 2011Article
- REC-2006-A Fractionated Extract of Podophyllum hexandrum Protects Cellular DNA from Radiation-Induced Damage by Reducing the Initial Damage and Enhancing Its Repair In Vivo.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Immunomodulatory Polysaccharide from Chlorophytum borivilianum Roots.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Ginsan enhances humoral antibody response to orally delivered antigen.Immune network · 2010Article
- The effects of celecoxib, a COX-2 selective inhibitor, on acute inflammation induced in irradiated rats.Inflammopharmacology · 2009Article
- Effect of North American ginseng on 137Cs-induced micronuclei in human lymphocytes: a comparison with WR-1065.Phytotherapy research : PTR · 2008Article
- Perillyl Alcohol Protects Against Fe-NTA-Induced Nephrotoxicity and Early Tumor Promotional Events in Rat Experimental Model.Evidence-based complementary and alternative medicine : eCAM · 2007Article
- Protective effect of Adhatoda vascia Nees against radiation-induced damage at cellular, biochemical and chromosomal levels in Swiss albino mice.Evidence-based complementary and alternative medicine : eCAM · 2007Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are numerous studies to indicate that irradiation induces reactive oxygen species (ROS), which play an important causative role in radiation damage of the cell. We evaluated the effects of ginsan, a polysaccharide fraction extracted from Panax ginseng, on the gamma-radiation induced alterations of some antioxidant systems in the spleen of Balb/c mice. On the 5th day after sublethal whole-body irradiation, homogenized spleen tissues of the irradiated mice expressed only marginally increased mRNA levels of Mn-SOD (superoxide dimutase) in contrast to Cu/Zn-SOD, however, catalase mRNA was decreased by approximately 50% of the control. In vivo treatment of non-irradiated mice with ginsan (100 mg kg(-1), intraperitoneal administration) had no significant effect, except for glutathione peroxidase (GPx) mRNA, which increased to 144% from the control. However, the combination of irradiation with ginsan effectively increased the SODs and GPx transcription as well as their protein expressions and enzyme activities. In addition, the expression of heme oxygenase-1 and non-protein thiol induced by irradiation was normalized by the treatment of ginsan. Evidence indicated that transforming growth factor-beta and other important cytokines such as IL-1, TNF and IFN-gamma might be involved in evoking the antioxidant enzymes. Therefore, we propose that the modulation of antioxidant enzymes by ginsan was partly responsible for protecting the animal from radiation, and could be applied as a therapeutic remedy for various ROS-related diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.