Evidence map›Paper›PMID 16322782›Full record

ReviewThe Journal of clinical investigation2005

Platelet genomics and proteomics in human health and disease.

Iain C Macaulay, Philippa Carr, Arief Gusnanto, Willem H Ouwehand, Des Fitzgerald, Nicholas A Watkins

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of clinical investigation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  15. Autologous platelet concentrates for facial rejuvenation.Journal of applied oral science : revista FOB · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Iain C MacaulayDepartment of Haematology, University of Cambridge, Cambridge, UK.
Philippa Carr
Arief Gusnanto
Willem H Ouwehand
Des Fitzgerald
Nicholas A Watkins

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteomic and genomic technologies provide powerful tools for characterizing the multitude of events that occur in the anucleate platelet. These technologies are beginning to define the complete platelet transcriptome and proteome as well as the protein-protein interactions critical for platelet function. The integration of these results provides the opportunity to identify those proteins involved in discrete facets of platelet function. Here we summarize the findings of platelet proteome and transcriptome studies and their application to diseases of platelet function.

Indexed as

Blood PlateletsComputational BiologyElectrophoresis, Gel, Two-DimensionalGene Expression ProfilingGenomeGenomicsHumansOligonucleotide Array Sequence AnalysisOligonucleotidesProtein Processing, Post-TranslationalProteomicsRNA, MessengerTranscription, GeneticOligonucleotidesRNA, Messenger

Identifiers

PMID16322782
PMCPMC1297260

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.