ArticleGenetics2006
Transcriptional reprogramming and backup between duplicate genes: is it a genomewide phenomenon?
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Moderate expression and activity of flocculins underlie the characteristic flocculation phenotype ofApplied and environmental microbiology · 2026Article
- Active compensation for changes in TDH3 expression mediated by direct regulators of TDH3 in Saccharomyces cerevisiae.PLoS genetics · 2023Article
- Article
- Article
- Mechanisms of mutational robustness in transcriptional regulation.Frontiers in genetics · 2015Review
- The effect of functional compensation among duplicate genes can constrain their evolutionary divergence.Journal of genetics · 2012Article
- Need-based up-regulation of protein levels in response to deletion of their duplicate genes.PLoS biology · 2010Article
- Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss.Molecular systems biology · 2007Article
- Differential deployment of paralogous Wnt genes in the mouse and chick embryo during development.Evolution & developmentArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deleting a duplicate gene often results in a less severe phenotype than deleting a singleton gene, a phenomenon commonly attributed to functional compensation among duplicates. However, duplicate genes rapidly diverge in expression patterns after duplication, making functional compensation less probable for ancient duplicates. Case studies suggested that a gene may provide compensation by altering its expression upon removal of its duplicate copy. On the basis of this observation and a genomic analysis, it was recently proposed that transcriptional reprogramming and backup among duplicates is a genomewide phenomenon in the yeast Saccharomyces cerevisiae. Here we reanalyze the yeast data and show that the high dispensability of duplicate genes with low expression similarity is a consequence of expression similarity and gene dispensability, each being correlated with a third factor, the number of protein interactions per gene. There is little evidence supporting widespread functional compensation of divergently expressed duplicate genes by transcriptional reprogramming.
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Registered trials
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