ArticleGenetics2006
A scan of molecular variation leads to the narrow localization of a selective sweep affecting both Afrotropical and cosmopolitan populations of Drosophila melanogaster.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Population Genomics on the Fly: Recent Advances in Drosophila.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Candidate loci involved in domestication and improvement detected by a published 90K wheat SNP array.Scientific reports · 2017Article
- Recent and recurrent selective sweeps of the antiviral RNAi gene Argonaute-2 in three species of Drosophila.Molecular biology and evolution · 2011Article
- Three selections are better than one: clinal variation of thermal QTL from independent selection experiments in Drosophila.Evolution; international journal of organic evolution · 2010Article
- Haplotype structure and expression divergence at the Drosophila cellular immune gene eater.Molecular biology and evolution · 2010Article
- Genetic hitchhiking versus background selection: the controversy and its implications.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Genome-wide patterns of adaptation to temperate environments associated with transposable elements in Drosophila.PLoS genetics · 2010Article
- Population genomics and speciation.Genetica · 2010Review
- Review
- Species-wide genetic variation and demographic history of Drosophila sechellia, a species lacking population structure.Genetics · 2009Article
- Estimation of fine-scale recombination intensity variation in the white-echinus interval of D. melanogaster.Journal of molecular evolution · 2009Article
- Tracking footprints of maize domestication and evidence for a massive selective sweep on chromosome 10.Proceedings of the National Academy of Sciences of the United States of America · 2009Review
- A branching process for the early spread of a transposable element in a diploid population.Journal of mathematical biology · 2008Article
- Hitchhiking both ways: effect of two interfering selective sweeps on linked neutral variation.Genetics · 2008Article
- Hitchhiking mapping reveals a candidate genomic region for natural selection in three-spined stickleback chromosome VIII.Genetics · 2008Article
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- Identification of selective sweeps using a dynamically adjusted number of linked microsatellites.Genetics · 2007Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Drosophila melanogaster originated in tropical Africa but has achieved a cosmopolitan distribution in association with human habitation. Cosmopolitan populations of D. melanogaster are known to have reduced genetic variation, particularly on the X chromosome. However, the relative importance of population bottlenecks and selective sweeps in explaining this reduction is uncertain. We surveyed variation at 31 microsatellites across a 330-kb section of the X chromosome located between the white and kirre genes. Two linked clusters of loci were observed with reduced variation and a skew toward rare alleles in both an Ecuador and a Zimbabwe population sample. Examining Zimbabwe DNA sequence polymorphism within one of these regions allowed us to localize a selective sweep to a 361-bp window within the 5' regulatory region of the roughest gene, with one nucleotide substitution representing the best candidate for the target of selection. Estimates of sweep age suggested that this fixation event occurred prior to the expansion of D. melanogaster from sub-Saharan Africa. For both putative sweep regions in our data set, cosmopolitan populations showed wider footprints of selection compared to those in Zimbabwe. This pattern appears consistent with the demographic amplification of preexisting sweep signals due to one or more population bottlenecks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.