ArticleGenetics2006
Patterns of diversity and linkage disequilibrium within the cosmopolitan inversion In(3R)Payne in Drosophila melanogaster are indicative of coadaptation.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- The Influence of Chromosomal Inversions on Genetic Variation and Clinal Patterns in Genomic Data of Drosophila melanogaster.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Genomics of natural populations: gene conversion events reveal selected genes within the inversions of Drosophila pseudoobscura.G3 (Bethesda, Md.) · 2024Article
- Long-Term Maintenance of Complex Chromosomal Inversion Polymorphism inEcology and evolution · 2024Article
- Chromosome-Length Assembly of the Baikal Seal (Genes · 2023Article
- Article
- An endangered flightless grasshopper with strong genetic structure maintains population genetic variation despite extensive habitat loss.Ecology and evolution · 2021Article
- Gene regulatory effects of a large chromosomal inversion in highland maize.PLoS genetics · 2020Article
- The Landscape of Micro-Inversions Provide Clues for Population Genetic Analysis of Humans.Interdisciplinary sciences, computational life sciences · 2020Article
- Genomic Analysis of European Drosophila melanogaster Populations Reveals Longitudinal Structure, Continent-Wide Selection, and Previously Unknown DNA Viruses.Molecular biology and evolution · 2020Article
- Conservation of gene architecture and domains amidst sequence divergence in theJournal of genetics · 2020Article
- Dobzhansky's concept of genetic coadaptation: Drosophila ananassae is an exception to this concept.Journal of genetics · 2018Article
- Patterns of geographic variation of thermal adapted candidate genes in Drosophila subobscura sex chromosome arrangements.BMC evolutionary biology · 2018Article
- EnhancingFrontiers in physiology · 2018Article
- Frequencies of chromosomal inversions in Drosophila melanogaster in Fukushima after the nuclear power plant accident.PloS one · 2018Article
- The Effect of Common Inversion PolymorphismsG3 (Bethesda, Md.) · 2017Article
- Young inversion with multiple linked QTLs under selection in a hybrid zone.Nature ecology & evolution · 2017Article
- Highly localized divergence within supergenes in Atlantic cod (Gadus morhua) within the Gulf of Maine.BMC genomics · 2017Article
- Chromosome inversions and ecological plasticity in the main African malaria mosquitoes.Evolution; international journal of organic evolution · 2017Article
- A collection of Australian Drosophila datasets on climate adaptation and species distributions.Scientific data · 2015Article
- The environmental genomics of metazoan thermal adaptation.Heredity · 2015Review
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3 authors.
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Abstract
The cosmopolitan inversion In(3R)Payne in Drosophila melanogaster decreases in frequency with increasing distance from the equator on three continents, indicating it is subject to strong natural selection. We investigated patterns of genetic variation and linkage disequilibrium (LD) in 24 molecular markers located within and near In(3R)Payne to determine if different parts of the inversion responded to selection the same way. We found reduced variation in the markers we used compared to others distributed throughout the genome, consistent with the inversion having a relatively recent origin (<N(e) generations). LD between markers and In(3R)Payne varied significantly among markers within the inversion, with regions of high association interspersed by regions of low association. Several factors indicate that these patterns were not due to demographic factors such as admixture and bottlenecks associated with colonization, but instead reflected strong epistatic selection. Furthermore, we found that nonadjacent regions with high association to the inversion contained markers with the strongest clinal patterns in allele frequency; in most cases, the level of clinal variation was beyond what could be explained by hitchhiking with In(3R)Payne, indicating that genes within these regions are targets of selection. Our results provide some support for the hypothesis that inversions persist in natural populations because they hold together favorable combinations of alleles that act together to facilitate adaptive shifts.
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