Evidence map›Paper›PMID 16322448›Full record

ReviewScience (New York, N.Y.)2005

The ins and outs of DNA transfer in bacteria.

Inês Chen, Peter J Christie, David Dubnau

Abstract readReview
In one paragraph

Review in Science (New York, N.Y.), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
177citing papers in PubMed, 1 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

177 citing papers in PubMed, 1 synthesis or guideline pooled it, 449 citations in OpenAlex.

  1. The Implication of Horizontal Gene Transfer BetweenPathogens (Basel, Switzerland) · 2026
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Micro-chimerism: from evolution to revolution.Seminars in immunopathology · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. New evidence supports the prophage origin of RcGTA.Applied and environmental microbiology · 2024
    Article
  19. Review
  20. Article

117 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Inês ChenPublic Health Research Institute, 225 Warren Street, Newark, NJ 07103, USA.
Peter J Christie
David Dubnau
The University of Texas Health Science Center at Houston · US

Funding

Understanding the mechanism of genetic transformationR01GM057720 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI DAVID A DUBNAU, Matthew B Neiditch · 1998 to 2026
$15.4M
GENETIC COMPETENCE APPARATUS OF BACILLUS SUBTILLISR01GM043756 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI DUBNAU, DAVID A · 1991 to 2016
$7.2M
TRANSLOCATION OF DNA ACROSS THE AGROBACTERIUM ENVELOPER01GM048746 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CHRISTIE, PETER J. · 1998 to 2018
$6.9M
TRANSLOCATION OF DNA ACROSS THE AGROBACTERIUM ENVELOPER29GM048746 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CHRISTIE, PETER J. · 1993 to 1997
–
NIGMS NIH HHS GM057720NIGMS NIH HHS GM43756NIGMS NIH HHS GM48746NIGMS NIH HHS R01 GM043756NIGMS NIH HHS R01 GM048746NIGMS NIH HHS R01 GM057720
6 · The paper itself

Abstract

Transformation and conjugation permit the passage of DNA through the bacterial membranes and represent dominant modes for the transfer of genetic information between bacterial cells or between bacterial and eukaryotic cells. As such, they are responsible for the spread of fitness-enhancing traits, including antibiotic resistance. Both processes usually involve the recognition of double-stranded DNA, followed by the transfer of single strands. Elaborate molecular machines are responsible for negotiating the passage of macromolecular DNA through the layers of the cell surface. All or nearly all the machine components involved in transformation and conjugation have been identified, and here we present models for their roles in DNA transport.

Indexed as

Conjugation, GeneticTransformation, BacterialDNA, BacterialDNA, Single-StrandedGene Transfer, HorizontalDNA, BacterialDNA, Single-Stranded

Identifiers

PMID16322448
PMCPMC3919525
OpenAlexW2025070182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.