ArticleLearning & memory (Cold Spring Harbor, N.Y.)
Reconsolidation of a context long-term memory in the terrestrial snail requires protein synthesis.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 60 citations in OpenAlex.
- DNA Methylation Inhibition Reversibly Impairs the Long-Term Context Memory Maintenance inInternational journal of molecular sciences · 2023Article
- Histone deacetylase inhibitors rescue the impaired memory in terrestrial snails.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- Effects of Thryptophan Hydroxylase Blockade by P-Chlorophenylalanine on Contextual Memory Reconsolidation after Training of Different Intensity.International journal of molecular sciences · 2020Article
- Impairing of Serotonin Synthesis by P-Chlorphenylanine Prevents the Forgetting of Contextual Memory After Reminder and the Protein Synthesis Inhibition.Frontiers in pharmacology · 2018Article
- Impairment of the serotonergic neurons underlying reinforcement elicits extinction of the repeatedly reactivated context memory.Scientific reports · 2016Article
- Transcription inhibitors prevent amnesia induced by NMDA antagonist-mediated impairment of memory reconsolidation.Learning & behavior · 2016Article
- A brief retraining regulates the persistence and lability of a long-term memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2010Article
- Reversible and irreversible stages in the development of amnesia after disruption of the reactivation of associative memory in snails.Neuroscience and behavioral physiology · 2010Article
- Reconsolidation and the fate of consolidated memories.Neurotoxicity research · 2008Review
- The conditioned reflex: detectors and command neurons.Neuroscience and behavioral physiology · 2008Review
- Retrieval induces hippocampal-dependent reconsolidation of spatial memory.Learning & memory (Cold Spring Harbor, N.Y.)Article
- On the role of hippocampal protein synthesis in the consolidation and reconsolidation of object recognition memory.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the influence of the protein synthesis blocker anisomycin on contextual memory in the terrestrial snail Helix. Prior to the training session, the behavioral responses in two contexts were similar. Two days after a session of electric shocks (5 d) in one context only, the context conditioning was observed as the significant difference of behavioral response amplitudes in two contexts. On the day following testing of context learning, a session of "reminding" was performed, immediately after which the snails were injected with anisomycin or vehicle. Testing of long-term context memory has shown that only anisomycin injections impaired the context conditioning. In control series, the snails were injected after the training session with anisomycin/saline without reminding, and no impairment of the long-term context memory was observed, while injection of anisomycin during the training session completely abolished the long-term memory. No effects of anisomycin on the short-term memory were observed. Surprisingly, injection of anisomycin after the reminding combined with reinforcing stimuli elicited no effect on the context memory. Differences between single-trial and multisession learning are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.