ArticleNucleic acids research2005
A haploid-specific transcriptional response to irradiation in Saccharomyces cerevisiae.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Review
- Transcriptional responses to DNA damage.DNA repair · 2019Review
- The genetics of a putative social trait in natural populations of yeast.Molecular ecology · 2014Article
- Transcriptional outcome of telomere signalling.Nature reviews. Genetics · 2014Review
- Structure and function in the budding yeast nucleus.Genetics · 2012Review
- Apparent ploidy effects on silencing are post-transcriptional at HML and telomeres in Saccharomyces cerevisiae.PloS one · 2012Article
- Adaptation of the black yeast Wangiella dermatitidis to ionizing radiation: molecular and cellular mechanisms.PloS one · 2012Article
- The budding yeast nucleus.Cold Spring Harbor perspectives in biology · 2010Review
- Segregating YKU80 and TLC1 alleles underlying natural variation in telomere properties in wild yeast.PLoS genetics · 2009Article
- A complex-based reconstruction of the Saccharomyces cerevisiae interactome.Molecular & cellular proteomics : MCP · 2009Article
- The functional importance of telomere clustering: global changes in gene expression result from SIR factor dispersion.Genome research · 2009Article
- Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network.Nature biotechnology · 2008Article
- Specific transcriptional responses induced by 8-methoxypsoralen and UVA in yeast.FEMS yeast research · 2007Article
- Inferring biological networks with output kernel trees.BMC bioinformatics · 2007Article
- InSite: a computational method for identifying protein-protein interaction binding sites on a proteome-wide scale.Genome biology · 2007Article
- Analyzing the dose-dependence of the Saccharomyces cerevisiae global transcriptional response to methyl methanesulfonate and ionizing radiation.BMC genomics · 2006Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eukaryotic cells respond to DNA damage by arresting the cell cycle and modulating gene expression to ensure efficient DNA repair. We used global transcriptome analysis to investigate the role of ploidy and mating-type in inducing the response to damage in various Saccharomyces cerevisiae strains. We observed a response to DNA damage specific to haploid strains that seemed to be controlled by chromatin regulatory proteins. Consistent with these microarray data, we found that mating-type factors controlled the chromatin-dependent silencing of a reporter gene. Both these analyses demonstrate the existence of an irradiation-specific response in strains (haploid or diploid) with only one mating-type factor. This response depends on the activities of Hdf1 and Sir2. Overall, our results suggest the existence of a new regulation pathway dependent on mating-type factors, chromatin structure remodeling, Sir2 and Hdf1 and independent of Mec1 kinase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.