ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2005
The oxygen sensing signal cascade under the influence of reactive oxygen species.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 61 citations in OpenAlex.
- HIF inhibition: Current strategies and clinical challenges.Redox biology · 2026Review
- Article
- Exposure to Palladium Nanoparticles Affects Serum Levels of Cytokines in Female Wistar Rats.PloS one · 2015Article
- Broad suppression of NADPH oxidase activity exacerbates ischemia/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1α and upregulation of peroxisome proliferator-activated receptor-α.Circulation research · 2013Article
- Current progress in Reactive Oxygen Species (ROS)-Responsive materials for biomedical applications.Advanced healthcare materials · 2013Review
- Modulation of K2P3.1 (TASK-1), K2P9.1 (TASK-3), and TASK-1/3 heteromer by reactive oxygen species.Pflugers Archiv : European journal of physiology · 2012Article
- Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesity.Journal of physiology and biochemistry · 2012Review
- Adenosine A₂a receptors and O₂ sensing in development.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Review
- Neuronal-astrocyte metabolic interactions: understanding the transition into abnormal astrocytoma metabolism.Journal of neuropathology and experimental neurology · 2011Review
- Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain.PLoS computational biology · 2011Article
- A membrane-bound vertebrate globin.PloS one · 2011Article
- Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions.The Journal of biological chemistry · 2009Article
- The role of NADPH oxidase in carotid body arterial chemoreceptors.Respiratory physiology & neurobiology · 2007Review
- Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Structural and functional integrity of organ function profoundly depends on a regular oxygen and glucose supply. Any disturbance of this supply becomes life threatening and may result in severe loss of organ function. Particular reductions in oxygen availability (hypoxia) caused by respiratory or blood circulation irregularities cannot be tolerated for longer periods due to an insufficient energy supply by anaerobic glycolysis. Complex cellular oxygen sensing systems have evolved to tightly regulate oxygen homeostasis. In response to variations in oxygen partial pressure (PO2), these systems induce adaptive and protective mechanisms to avoid or at least minimize tissue damage. These various responses might be based on a range of oxygen sensing signal cascades including an isoform of the neutrophil NADPH oxidase, different electron carrier units of the mitochondrial chain such as a specialized mitochondrial, low PO2 affinity cytochrome c oxidase (aa3) and a subfamily of 2-oxoglutarate dependent dioxygenases termed HIF (hypoxia inducible factor) prolyl-hydroxylase and HIF asparaginyl hydroxylase called factor-inhibiting HIF (FIH-1). Thus, specific oxygen sensing cascades involving reactive oxygen species as second messengers may by means of their different oxygen sensitivities, cell-specific and subcellular localization help to tailor various adaptive responses according to differences in tissue oxygen availability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.