ArticleJournal of molecular evolution2006
Fast accumulation of nonsynonymous mutations on the female-specific W chromosome in birds.
Article in Journal of molecular evolution, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Article
- Evolution, Inheritance, and Strata Formation of the W Chromosome in Duck (Anas platyrhynchos).Genome biology and evolution · 2023Article
- Parallel Evolution of Sex-Linked Genes across XX/XY and ZZ/ZW Sex Chromosome Systems in the FrogGenes · 2023Article
- Tempo of Degeneration Across Independently Evolved Nonrecombining Regions.Molecular biology and evolution · 2022Article
- Article
- Evolution of recombination rates between sex chromosomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Evolutionary analysis of the female-specific avian W chromosome.Nature communications · 2015Article
- Complex evolutionary trajectories of sex chromosomes across bird taxa.Science (New York, N.Y.) · 2014Article
- Independent stratum formation on the avian sex chromosomes reveals inter-chromosomal gene conversion and predominance of purifying selection on the W chromosome.Evolution; international journal of organic evolution · 2014Article
- Article
- Avian sex, sex chromosomes, and dosage compensation in the age of genomics.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2014Review
- Population size dependence of fitness effect distribution and substitution rate probed by biophysical model of protein thermostability.Genome biology and evolution · 2013Article
- The key role of repeated DNAs in sex chromosome evolution in two fish species with ZW sex chromosome system.Molecular cytogenetics · 2012Article
- W chromosome expression responds to female-specific selection.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The effect of variation in the effective population size on the rate of adaptive molecular evolution in eukaryotes.Genome biology and evolution · 2012Article
- Identification of mediator complex 26 (Crsp7) gametologs on platypus X1 and Y5 sex chromosomes: a candidate testis-determining gene in monotremes?Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- Article
- Sex-chromosome evolution: recent progress and the influence of male and female heterogamety.Nature reviews. Genetics · 2011Review
- Lack of global dosage compensation in Schistosoma mansoni, a female-heterogametic parasite.Genome biology and evolution · 2011Article
- Signatures of selection in loci governing major colour patterns in Heliconius butterflies and related species.BMC evolutionary biology · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following cessation of recombination during sex chromosome evolution, the nonrecombining sex chromosome is affected by a number of degenerative forces, possibly resulting in the fixation of deleterious mutations. This might take place because of weak selection against recessive or partly recessive deleterious mutations due to permanent heterozygosity of nonrecombining chromosomes. Furthermore, population genetic processes, such as selective sweeps, background selection, and Muller's ratchet, result in a reduction in Ne, which increase the likelihood of fixation of deleterious mutations. Theory thus predicts that nonrecombining genes should show increased levels of nonsynonymous (dN) to synonymous substitutions (dS). We tested this in an avian system by estimating the ratio between dN and dS in six gametologous gene pairs located on the Z chromosome and the nonrecombining, female-specific W chromosome. In comparisons, we found a significantly higher dN/dS ratio for the W-linked than the Z-linked copy in three of the investigated genes. In a concatenated alignment of all six genes, the dN/dS ratio was six times higher for W-linked than Z-linked genes. By using human and mouse as outgroup in maximum likelihood analyses, W-linked genes were found to evolve differently compared with their Z-linked gametologues and outgroup sequences. This seems not to be a consequence of functional diversification because d(N)/d(S) ratios between gametologous gene copies were consistently low. We conclude that deleterious mutations are accumulating at a high rate on the avian W chromosome, probably as a result of the lack of recombination in this female-specific chromosome.
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