ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2006
Conditional mutations in SERCA, the Sarco-endoplasmic reticulum Ca2+-ATPase, alter heart rate and rhythmicity in Drosophila.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Neprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides.Nature communications · 2022Article
- Effect of Temperature on Heart Rate forInsects · 2021Article
- Identification of a pathogenic mutation in ATP2A1 via in silico analysis of exome data for cryptic aberrant splice sites.Molecular genetics & genomic medicine · 2019Article
- Sources of CaJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Article
- SERCA is critical to control the Bowditch effect in the heart.Scientific reports · 2018Article
- SERCA directs cell migration and branching across species and germ layers.Biology open · 2017Article
- Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations.PLoS genetics · 2017Article
- CRISPR-Cas-Induced Mutants Identify a Requirement for dSTIM in Larval Dopaminergic Cells ofG3 (Bethesda, Md.) · 2017Article
- Probing the Fractal Pattern of Heartbeats in Drosophila Pupae by Visible Optical Recording System.Scientific reports · 2016Article
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- Aging and CaMKII alter intracellular Ca2+ transients and heart rhythm in Drosophila melanogaster.PloS one · 2014Article
- Pharmacological analysis of dopamine modulation in the Drosophila melanogaster larval heart.Physiological reports · 2013Article
- Comparative approaches to the study of physiology: Drosophila as a physiological tool.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Review
- Disruption of sarcoendoplasmic reticulum calcium ATPase function in Drosophila leads to cardiac dysfunction.PloS one · 2013Article
- Inhibition of ion channels and heart beat in Drosophila by selective COX-2 inhibitor SC-791.PloS one · 2012Article
- Drosophila models of cardiac disease.Progress in molecular biology and translational science · 2011Review
- A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.Cell · 2010Article
- A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts.BioTechniques · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
To analyze the role of cytosolic calcium in regulating heart beat frequency and rhythm, we studied conditional mutations in Drosophila Sarco-endoplasmic reticulum Ca2+-ATPase, believed to be predominantly responsible for sequestering free cytosolic calcium. Abnormalities in the amount or structure of the SERCA protein have been linked to cardiac malfunction in mammals. Drosophila SERCA protein (dSERCA) is highly enriched in Drosophila larval heart with a distinct membrane distribution of SERCA at cardiac Z-lines, suggesting evolutionarily conserved zones for calcium uptake into the sarcoplasmic reticulum. Heart beat frequency is strikingly reduced in mutant animals following dSERCA inactivation, (achieved by a brief exposure of these conditional mutants to non-permissive temperature). Cardiac contractions also show abnormal rhythmicity and electrophysiological recordings from the heart muscle reveal dramatic alterations in electrical activity. Overall, these studies underscore the utility of the Drosophila heart to model SERCA dysfunction dependent cardiac disorders and constitute an initial step towards developing Drosophila as a viable genetic model system to study conserved molecular determinants of cardiac physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.