ArticlePharmaceutical research2006
New cyclodextrin hydrogels cross-linked with diglycidylethers with a high drug loading and controlled release ability.
Article in Pharmaceutical research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Multifunctional Drug Delivery System: Nanosponges.Recent patents on nanotechnology · 2025Review
- Advancements in application of chitosan and cyclodextrins in biomedicine and pharmaceutics: recent progress and future trends.RSC advances · 2024Review
- Evaluation of the Swelling Properties and Sorption Capacity of Maltodextrin-Based Cross-Linked Polymers.Gels (Basel, Switzerland) · 2024Article
- Development and Characterization of Cyclodextrin-Based Nanogels as a New Ibuprofen Cutaneous Delivery System.Pharmaceutics · 2022Article
- Nutraceutical Concepts and Dextrin-Based Delivery Systems.International journal of molecular sciences · 2022Review
- One-step sustainable synthesis of cationic high-swelling polymers obtained from starch-derived maltodextrins.RSC advances · 2021Article
- Article
- Cyclodextrins in drug delivery: applications in gene and combination therapy.Drug delivery and translational research · 2020Review
- Electrospun crosslinked poly-cyclodextrin nanofibers: Highly efficient molecular filtration thru host-guest inclusion complexation.Scientific reports · 2017Article
- Cross-linked β-cyclodextrin and carboxymethyl cellulose hydrogels for controlled drug delivery of acyclovir.PloS one · 2017Article
- High-efficiency loading and controlled release of highly water-soluble drug, pravastatin sodium by use of cross-linked β-cyclodextrin.International journal of pharmaceutical investigation · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe goal of the study is to develop new hydrogels based on cyclodextrins cross-linked with ethyleneglycol diglycidylether (EGDE) under mild conditions, to be used as carriers of amphiphilic drugs. Also, it aims to characterize the cross-linking and the drug loading and release processes.
methodsThe cross-linking of hydroxypropyl-beta-cyclodextrin (HPbetaCD) with EGDE, in the absence or presence of hydroxypropylmethylcellulose (HPMC) Methocel K4M, was optimized applying oscillatory rheometry and Fourier transform infrared. Hydrogels were characterized regarding swelling in water, ability to load diclofenac, and release after different drying treatments.
resultsSolutions of HPbetaCD (14.28%), without or with HPMC (0.2-1.0%), provided firm and transparent hydrogels after cross-linking with EGDE (14.28%), in which around two thirds of the OH groups were cross-linked. The incorporation of HPMC progressively reduced the gel time and the swelling degree of hydrogels. HPbetaCD hydrogels efficiently loaded diclofenac and sustained the release for several hours. The presence of HPMC slowed the release from swollen hydrogels, but promoted it from hydrogels dried before the loading and also before the release.
conclusionsHPbetaCD hydrogels with good mechanical properties and tunable loading and release ability can be obtained by direct cross-linking with EGDE.
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Identifiers
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Registered trials
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