ReviewJournal of perinatology : official journal of the California Perinatal Association2006
Brain lesions in newborns exposed to high-dose magnesium sulfate during preterm labor.
Review in Journal of perinatology : official journal of the California Perinatal Association, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 61 citations in OpenAlex.
- Effects of magnesium sulfate combined with labetalol on vascular endothelial function and pregnancy outcomes in pregnant women with preeclampsia.American journal of translational research · 2024Article
- Effects of MgSOInternational journal of molecular sciences · 2022Article
- Effect of Neuroprotective Magnesium Sulfate Treatment on Brain Transcription Response to Hypoxia Ischemia in Neonate Mice.International journal of molecular sciences · 2021Article
- The effects of maternal body mass index and plurality on maternal and umbilical cord serum magnesium levels in preterm birth at less than 32 weeks of gestation.Obstetrics & gynecology science · 2021Article
- The effect of antenatal magnesium sulfate on intraventricular hemorrhage in premature infants: a systematic review and meta-analysis.Obstetrics & gynecology science · 2020Article
- Fetal Neuroprotection by Magnesium Sulfate: From Translational Research to Clinical Application.Frontiers in neurology · 2018Review
- Experimental and clinical evidence of differential effects of magnesium sulfate on neuroprotection and angiogenesis in the fetal brain.Pharmacology research & perspectives · 2017Article
- Effects of antenatal magnesium sulfate treatment for neonatal neuro-protection on cerebral oxygen kinetics.Pediatric research · 2015Observational
- Neurotrophin-induced migration and neuronal differentiation of multipotent astrocytic stem cells in vitro.PloS one · 2012Article
- Antenatal magnesium sulfate and the postnatal response of the ductus arteriosus to indomethacin in extremely preterm neonates.Journal of perinatology : official journal of the California Perinatal Association · 2011Article
- High dose magnesium sulfate exposure induces apoptotic cell death in the developing neonatal mouse brain.Neonatology · 2009Article
- Risk factors and clinical outcomes of pulmonary interstitial emphysema in extremely low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2006Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-dosage, tocolytic magnesium sulfate (MgSO4) administered to pregnant women during preterm labor can be toxic, and sometimes lethal, for their newborns (Cochrane Database of Systematic Reviews (relative mortality risk 2.82, 95% confidence interval 1.2-6.6)). Based on the results of the Magnesium and Neurologic Endpoints Trial and the work of many others, a unifying triangular concept is proposed to account for the increased prevalence of brain lesions, with their likely resultant mortality, in neonates and infants exposed to high-dose MgSO4 in the context of preterm labor. We review the evidence that: (1) elevated circulating levels of serum ionized magnesium occurring in mothers, and therefore in their babies, at the time of delivery are associated with subsequent neonatal intraventricular hemorrhage (IVH); (2) neonatal IVH is strongly associated with lenticulostriate vasculopathy (LSV), an unusual mineralizing lesion involving the thalami and basal ganglia of the neonate; and, (3) exposure to 50 g or more of tocolytic MgSO4 during preterm labor is associated with the development of LSV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.