Evidence map›Paper›PMID 16319386›Full record

ReviewThe New England journal of medicine2005

Low-dose aspirin for the prevention of atherothrombosis.

Carlo Patrono, Luis A García Rodríguez, Raffaele Landolfi, Colin Baigent

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in The New England journal of medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 365 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
365citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00594867 phase4completednot on this mapstarted 2006, after this paper: background citation

Does Acetaminophen Potentiate the Gastroduodenal Mucosal Injury of Aspirin? A Prospective, Randomized, Pilot Study.

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2006 to 2007Enrolled94ConditionsHealthyArmsAcetaminophen - 4 grams per day + Placebo, Aspirin - 325 mg per day + Placebo, Acetaminophen 4 gram per day + Aspirin 325 mg per day
NCT02409680 nacompletednot on this mapstarted 2016, after this paper: background citation

Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)

TypeinterventionalSponsorNICHD Global Network for Women's and Children's HealthRan2016 to 2019Enrolled11,976ConditionsPremature BirthArmsLow dose aspirin, Placebo
3 · Its place in the literature

Who cites it

365 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Pooled it
  2. The Anti-Metastatic Role of Aspirin in Cancer: A Systematic Review.International journal of molecular sciences · 2026
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  12. Trial
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  19. The aspirin in reducing events in the elderly trial: Statistical analysis plan.International journal of stroke : official journal of the International Stroke Society · 2018
    Trial
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305 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Carlo PatronoDepartment of Pharmacology, University of Rome La Sapienza, Rome, Italy. cpatrono@unich.it
Luis A García Rodríguez
Raffaele Landolfi
Colin Baigent

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ArteriosclerosisAspirinCyclooxygenase 1Cyclooxygenase InhibitorsDrug InteractionsDrug ResistanceGastrointestinal HemorrhageHumansMaleMyocardial InfarctionPlatelet Aggregation InhibitorsRiskStrokeThrombosisThromboxane A2AspirinCyclooxygenase 1Cyclooxygenase InhibitorsPlatelet Aggregation InhibitorsThromboxane A2

Identifiers

PMID16319386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.