ArticleTobacco control2005
Use of nicotine replacement therapy and the risk of acute myocardial infarction, stroke, and death.
Article in Tobacco control, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Smoking-cessation pharmacotherapy for patients with stroke and TIA: Systematic review.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2020Pooled it
- A systematic review of possible serious adverse health effects of nicotine replacement therapy.Archives of toxicology · 2017Pooled it
- Effects on abstinence of nicotine patch treatment before quitting smoking: parallel, two arm, pragmatic randomised trial.BMJ (Clinical research ed.) · 2018Trial
- Brief exposure to Swedish snus causes divergent vascular responses in healthy male and female volunteers.PloS one · 2018Trial
- Economic evaluation of a telephone- and face-to-face-delivered counseling intervention for smoking cessation in patients with coronary heart disease.The European journal of health economics : HEPAC : health economics in prevention and care · 2016Trial
- The Combined Effect of Smoking and Obesity on Hypertension: Implications for Clinical Management.Current hypertension reviews · 2025Review
- Association between baseline smoking status and clinical outcomes following myocardial infarction.Frontiers in cardiovascular medicine · 2022Article
- Risk of neuropsychiatric and cardiovascular adverse events following treatment with varenicline and nicotine replacement therapy in the UK Clinical Practice Research Datalink: a case-cross-over study.Addiction (Abingdon, England) · 2021Article
- Association between smoking status and outcomes in myocardial infarction patients undergoing percutaneous coronary intervention.Scientific reports · 2021Article
- Article
- Cardiovascular risks in smokers treated with nicotine replacement therapy: a historical cohort study.Clinical epidemiology · 2017Article
- Expression Changes of Apoptotic Genes in Tissues from Mice Exposed to NicotineAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Putting tobacco harm reduction in perspective: is it a viable alternative?The Indian journal of medical research · 2016Article
- Comparison of the characteristics of long-term users of electronic cigarettes versus nicotine replacement therapy: A cross-sectional survey of English ex-smokers and current smokers.Drug and alcohol dependence · 2015Article
- "Tobacco dependence treatment makes no sense because"…: rebuttal of commonly-heard arguments against providing tobacco dependence treatment in the hospital setting.BMC public health · 2014Review
- Article
- Safety evaluation and risk assessment of electronic cigarettes as tobacco cigarette substitutes: a systematic review.Therapeutic advances in drug safety · 2014Review
- Downregulation of miR-133 via MAPK/ERK signaling pathway involved in nicotine-induced cardiomyocyte apoptosis.Naunyn-Schmiedeberg's archives of pharmacology · 2014Article
- Prevalence of NRT use and associated nicotine intake in smokers, recent ex-smokers and longer-term ex-smokers.PloS one · 2014Article
- Use of varenicline for smoking cessation and risk of serious cardiovascular events: nationwide cohort study.BMJ (Clinical research ed.) · 2012Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo determine whether nicotine replacement therapy (NRT) is associated with an increased risk of acute myocardial infarction, acute stroke, or death.
designSelf control case series analysis of data from The Health Improvement Network (THIN) to estimate the relative incidence of myocardial infarction and stroke in four 14 day periods before and after the first prescription for NRT.
settingTHIN is a computerised general practice database. SUBJECTS: Patients contributing data to THIN.
interventionsObservational study of NRT. MAIN OUTCOMES: Acute myocardial infarction, acute stroke, and death.
results33,247 individuals had been prescribed NRT, of whom 861 had had a myocardial infarction and 506 a stroke. There was a progressive increase in the incidence of first myocardial infarction in the 56 days leading up to the first NRT prescription (overall incidence ratio 5.55, 95% confidence interval (CI) 4.42 to 6.98), but the incidence fell after this time and was not increased in the 56 days after starting NRT (incidence ratio 1.27, 95% CI 0.82 to 1.97). The results were similar for second myocardial infarction and stroke, and for subgroups of people with pre-existing angina and hypertension. There were 960 deaths in our cohort during a mean follow up period of 2.6 years after starting NRT, with no evidence of an increased mortality in the 56 days after the NRT prescription (incidence ratio 0.86, 95% CI 0.60 to 1.23).
conclusionsThe use of NRT is not associated with any increase in the risk of myocardial infarction, stroke, or death.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.