ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Mechanism of signal amplification in the olfactory sensory cilia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 45 citations in OpenAlex.
- Olfactory cilia, regulation and control of olfaction.Physiological reports · 2024Review
- Segregation of Ca2+ signaling in olfactory signal transduction.The Journal of general physiology · 2023Article
- Second messenger molecules have a limited spread in olfactory cilia.The Journal of general physiology · 2018Article
- Antagonism in olfactory receptor neurons and its implications for the perception of odor mixtures.eLife · 2018Article
- 2,4,6-trichloroanisole is a potent suppressor of olfactory signal transduction.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Neural coding of binary mixtures in a structurally related odorant pair.Scientific reports · 2013Article
- A dynamical feedback model for adaptation in the olfactory transduction pathway.Biophysical journal · 2012Article
- Molecular components of signal amplification in olfactory sensory cilia.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Modelling and sensitivity analysis of the reactions involving receptor, G-protein and effector in vertebrate olfactory receptor neurons.Journal of computational neuroscience · 2009Article
- Activation and desensitization of the olfactory cAMP-gated transduction channel: identification of functional modules.The Journal of general physiology · 2009Article
- Mechanism of olfactory masking in the sensory cilia.The Journal of general physiology · 2009Article
- Primary processes in sensory cells: current advances.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2009Review
- An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexes.PLoS genetics · 2008Article
- Distribution, amplification, and summation of cyclic nucleotide sensitivities within single olfactory sensory cilia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Disynaptic amplification of metabotropic glutamate receptor 1 responses in the olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Odorant inhibition of the olfactory cyclic nucleotide-gated channel with a native molecular assembly.The Journal of general physiology · 2006Article
- Fast adaptation in mouse olfactory sensory neurons does not require the activity of phosphodiesterase.The Journal of general physiology · 2006Article
- Calmodulin contributes to gating control in olfactory calcium-activated chloride channels.The Journal of general physiology · 2006Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular mechanisms underlying olfactory signal amplification were investigated by monitoring cAMP dynamics in the intact sensory cilia. We saw that [cAMP]i increased superlinearly with time during odorant stimuli for >1 s. This time course was remarkably different from that obtained with the rapid quench method previously applied to the in vitro preparation, in which [cAMP]i change has been reported to be transient. The superlinear increase of [cAMP]i was attributable to a gradual increase of cAMP production rate that was consistent with the thermodynamical interaction model between elemental molecules, as has been revealed on the rod photoreceptor cell. It thus seems likely that the fundamental mechanism for molecular interactions between olfactory transduction elements is similar to that of the rod. In olfaction, however, cAMP production was extremely small (approximately 200,000 molecules/s/cell at the maximum), in contrast to the cGMP hydrolysis in the rod (250,000 molecules/photon). The observed numbers indicate that the olfactory receptor cell has lower amplification at the enzymatic cascade. Seemingly, such low amplification is a disadvantage for the signal transduction, but this unique mechanism would be essential to reduce the loss of ATP that is broadly used for the activities of cells. Apparently, transduction by a smaller number of second-messenger formations would be achieved by the fine ciliary structure that has a high surface-volume ratio. In addition, it is speculated that this low amplification at their enzymatic processes may be the reason why the olfactory receptor cell has acquired high amplification at the final stage of transduction channels, using Ca2+ as a third messenger.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.