ArticleMolecular biology of the cell2006
Two independent pathways traffic the intraperoxisomal peroxin PpPex8p into peroxisomes: mechanism and evolutionary implications.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Building peroxisomes: perspectives on plant peroxins.Biochemical Society transactions · 2026Review
- Characterization ofJournal of fungi (Basel, Switzerland) · 2026Article
- Identifying and characterizing a missing peroxin-PEX8-in Arabidopsis thaliana.The Plant cell · 2025Article
- Towards solving the mystery of peroxisomal matrix protein import.Trends in cell biology · 2024Review
- The autophagic degradation of cytosolic pools of peroxisomal proteins by a new selective pathway.Autophagy · 2020Article
- Saccharomyces cerevisiae cells lacking Pex3 contain membrane vesicles that harbor a subset of peroxisomal membrane proteins.Biochimica et biophysica acta. Molecular cell research · 2017Article
- Random Effects Model for Multiple Pathway Analysis with Applications to Type II Diabetes Microarray Data.Statistics in biosciences · 2015Article
- The unique degradation pathway of the PTS2 receptor, Pex7, is dependent on the PTS receptor/coreceptor, Pex5 and Pex20.Molecular biology of the cell · 2014Article
- Preperoxisomal vesicles can form in the absence of Pex3.The Journal of cell biology · 2014Article
- Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy.The Journal of cell biology · 2014Article
- Redox-regulated cargo binding and release by the peroxisomal targeting signal receptor, Pex5.The Journal of biological chemistry · 2013Article
- The exportomer: the peroxisomal receptor export machinery.Cellular and molecular life sciences : CMLS · 2013Review
- Unique requirements for mono- and polyubiquitination of the peroxisomal targeting signal co-receptor, Pex20.The Journal of biological chemistry · 2013Article
- Recent advances in peroxisomal matrix protein import.Current opinion in cell biology · 2012Review
- Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1.PLoS biology · 2012Article
- Peroxisome assembly: matrix and membrane protein biogenesis.The Journal of cell biology · 2011Review
- Pex2 and pex12 function as protein-ubiquitin ligases in peroxisomal protein import.Molecular and cellular biology · 2009Article
- The peroxisomal matrix import of Pex8p requires only PTS receptors and Pex14p.Molecular biology of the cell · 2009Article
- Peroxisome matrix and membrane protein biogenesis.IUBMB life · 2009Review
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3 authors.
Funding
Abstract
Among peroxins involved in peroxisome biogenesis, only Pex8p is predominantly intraperoxisomal at steady state. Pex8p is necessary for peroxisomal matrix protein import via the PTS1 and PTS2 pathways. It is proposed to bridge two peroxisomal membrane subcomplexes comprised of the docking (Pex13p, Pex14p, Pex17p) and RING (Pex2p, Pex10p, Pex12p) peroxins and is also implicated in cargo release of PTS1 proteins in the matrix. We show that Pichia pastoris Pex8p (PpPex8p) enters the peroxisome matrix using two redundant pathways in a Pex14p-dependent, but Pex2p-independent, manner, showing that the intact importomer and RING subcomplex are not required for its import. One pathway depends on the TPR motifs in Pex5p, the C-terminal PTS1 sequence (AKL) in PpPex8p, and the intraperoxisomal presence of this peroxin. The alternative pathway uses the PTS2 receptor, Pex7p, its accessory protein, Pex20p, and a putative PTS2 motif in PpPex8p, but does not require intraperoxisomal PpPex8p. Pex20p interaction with PpPex8p is independent of Pex7p, but the interaction of PpPex8p with Pex7p requires Pex20p. These data suggest a direct interaction between PpPex8p and Pex20p. Our studies shed light on the mechanism and evolution of the dual import pathways for PpPex8p.
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