Evidence map›Paper›PMID 16319077›Full record

ArticleBiophysical journal2005

From shut to open: what can we learn from linear free energy relationships?

David Colquhoun

Abstract readComment
In one paragraph

Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Φ value analysis underscores strong functional and structural compactness of the GABAProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. Linear rate-equilibrium relations arising from ion channel-bilayer energetic coupling.Proceedings of the National Academy of Sciences of the United States of America · 2011
    Article
  4. Review
  5. Article
  6. Unliganded gating of acetylcholine receptor channels.Proceedings of the National Academy of Sciences of the United States of America · 2009
    Article
  7. Structural answers and persistent questions about how nicotinic receptors work.Frontiers in bioscience : a journal and virtual library · 2008
    Review
  8. Agonist-activated ion channels.British journal of pharmacology · 2006
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

David ColquhounDepartment of Pharmacology, University College London, London, United Kingdom. d.colquhoun@ucl.ac.uk

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Models, BiologicalModels, ChemicalComputer SimulationIon Channel GatingIon ChannelsLinear Energy TransferMembrane PotentialsIon Channels

Identifiers

PMID16319077
PMCPMC1366935

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.