Evidence map›Paper›PMID 16318719›Full record

ArticleEmerging infectious diseases2005

Cryptococcus gattii in AIDS patients, southern California.

Sudha Chaturvedi, Madhu Dyavaiah, Robert A Larsen, Vishnu Chaturvedi

Open access · diamondAbstract readComparative StudyEvaluation Study
In one paragraph

Article in Emerging infectious diseases, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Peptides fromFuture microbiology · 2025
    Article
  4. Review
  5. Gene, virulence and related regulatory mechanisms inActa biochimica et biophysica Sinica · 2022
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Management of Cryptococcus gattii meningoencephalitis.The Lancet. Infectious diseases · 2015
    Review
  14. IsJournal of fungi (Basel, Switzerland) · 2015
    Article
  15. Review
  16. Cryptococcus gattii infections.Clinical microbiology reviews · 2014
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Sudha ChaturvediMycology Laboratory, Wadsworth Center, 120 New Scotland Avenue, Albany, NY 12208-2002, USA.
Madhu Dyavaiah
Robert A Larsen
Vishnu Chaturvedi
Wadsworth Center · USUniversity at Albany, State University of New York · USUniversity of Southern California · US

Funding

SUPEROXIDE DISMUTASE OF CRYPTOCOCCUS NEOFORMANSR01AI048462 · NIAID · WADSWORTH CENTER · PI CHATURVEDI, SUDHA · 2001 to 2004
$895k
CRYPTOCOCCUS NEOFORMANS--OXIDATIVE KILLING MECHANISMSR29AI041968 · NIAID · WADSWORTH CENTER · PI CHATURVEDI, VISHNU · 1997 to 2001
$226k
Cryptococcus gatti mating loci;mapping and gene studyR03AI053732 · NIAID · WADSWORTH CENTER · PI CHATURVEDI, VISHNU · 2003 to 2004
$159k
NIAID NIH HHS AI 41968NIAID NIH HHS AI 48462NIAID NIH HHS AI 53732NIAID NIH HHS R01 AI048462NIAID NIH HHS R03 AI053732
6 · The paper itself

Abstract

Cryptococcus isolates from AIDS patients in southern California were characterized by molecular analyses. Pheromone MFalpha1 and MFa1 gene fragments were polymerase chain reaction-amplified with fluorescently labeled primers and analyzed by capillary electrophoresis (CE) on DNA analyzer. CE-fragment-length analyses (CE-FLAs) and CE-single-strand conformation polymorphisms (CE-SSCPs) were used to determine Cryptococcus gattii (Cg), C. neoformans (Cn) varieties neoformans (CnVN) and grubii (CnVG), mating types, and hybrids. Corroborative tests carried out in parallel included growth on specialized media and serotyping with a commercial kit. All 276 clinical strains tested as haploid MATalpha by CE-FLA. CE-SSCP analyses of MFalpha1 showed 219 (79.3%) CnVG, 23 (8.3%) CnVN, and 34 (12.3%) Cg isolates. CE-FLA and CE-SSCP are promising tools for high-throughput screening of Cryptococcus isolates. The high prevalence of Cg was noteworthy, in view of its sporadic reports from AIDS patients in North America and its recent emergence as a primary pathogen on Vancouver Island, Canada.

Indexed as

AIDS-Related Opportunistic InfectionsCaliforniaCryptococcosisCryptococcusCulture MediaDNA PrimersElectrophoresis, CapillaryFungal ProteinsHIV InfectionsHumansMycological Typing TechniquesPheromonesPolymerase Chain ReactionPolymorphism, Single-Stranded ConformationalReagent Kits, DiagnosticSerotypingCulture MediaDNA PrimersFungal ProteinsPheromonesReagent Kits, Diagnostic

Identifiers

PMID16318719
PMCPMC3367345
OpenAlexW1983947294

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.