ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2006
Electroaffinity in paracellular absorption of hydrophilic D-dipeptides by sparrow intestine.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Comparative digestive physiology.Comprehensive Physiology · 2013Review
- The capacity for paracellular absorption in the insectivorous bat Tadarida brasiliensis.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2013Article
- Paracellular absorption is relatively low in the herbivorous Egyptian spiny-tailed lizard, Uromastyx aegyptia.PloS one · 2013Article
- Capacity for absorption of water-soluble secondary metabolites greater in birds than in rodents.PloS one · 2012Article
- The digestive adaptation of flying vertebrates: high intestinal paracellular absorption compensates for smaller guts.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously demonstrated size selectivity in the absorption of nonelectrolyte hydrosoluble probes in birds, presumably by the paracellular pathway. Our goal in this study was to determine the charge selectivity in the absorption of hydrosoluble D-dipeptides, because there have been no studies of the electroaffinity of this absorption pathway in birds. For this purpose isosmotic solutions with two hydrophilic D-dipeptides: serine-lysine (positive at pH 7.4) and serine-aspartic (negative at pH 7.4) were gavaged into the stomach in nonanesthetized house sparrows (Passer domesticus), and injected into the pectoralis with a syringe in different trials. Fractional absorption was calculated as F = [AUC by gavage)]/[AUC by injection] (AUC = area under the curve of plasma probe concentration vs. time). Fractional absorption was significantly higher for the positively charged than negatively charged dipeptide (respectively, F=0.30+/-0.05 vs. F=0.17+/-0.03). These findings give the first evidence of cation selectivity by the paracellular route in the absorption of hydrosoluble solutes in the small intestine in birds.
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