ArticleTransgenic research2005
The serine/threonine kinase, Krct, affects endbud morphogenesis during murine mammary gland development.
Article in Transgenic research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Recent progress in discovery of novel AAK1 inhibitors: from pain therapy to potential anti-viral agents.Journal of enzyme inhibition and medicinal chemistry · 2023Review
- The STK16 inhibitor STK16-IN-1 inhibits non-adrenergic and non-neurogenic smooth muscle contractions in the human prostate and the human male detrusor.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Serine/Threonine Protein Kinase STK16.International journal of molecular sciences · 2019Review
- Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.Structure (London, England : 1993) · 2016Article
- Serine/threonine kinase 16 and MAL2 regulate constitutive secretion of soluble cargo in hepatic cells.The Biochemical journal · 2014Article
- Distinct palmitoylation events at the amino-terminal conserved cysteines of Env7 direct its stability, localization, and vacuolar fusion regulation in S. cerevisiae.The Journal of biological chemistry · 2014Article
- Saccharomyces cerevisiae Env7 is a novel serine/threonine kinase 16-related protein kinase and negatively regulates organelle fusion at the lysosomal vacuole.Molecular and cellular biology · 2013Article
- CrkII transgene induces atypical mammary gland development and tumorigenesis.The American journal of pathology · 2010Article
- Distinct effects of calorie restriction and exercise on mammary gland gene expression in C57BL/6 mice.Cancer prevention research (Philadelphia, Pa.) · 2009Article
- Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture.Structure (London, England : 1993) · 2008Article
- Pubertal mammary gland development: insights from mouse models.Journal of mammary gland biology and neoplasia · 2006Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
STK16/Krct (Kinase related to cerevisiae and thaliana) is a ubiquitously expressed member of a unique family of serine/threonine protein kinases that is conserved among all eukaryotes. Despite its cloning 6 years ago to date, the function of this kinase remains unknown. In an attempt to identify a function for Krct, we have generated a doxycycline-dependent transgenic mouse model that permits the inducible overexpression of Krct in the mammary glands of mice treated with tetracycline derivatives. Analysis of these mice reveals that modest overexpression of Krct in the mammary gland during puberty results in duplication of the terminal endbud axis such that multiple, rather than single, budding structures arise at the ends of primary ducts. Supernumerary endbuds in Krct overexpressing mice resemble wild-type terminal endbuds with regard to cellular proliferation rates and localization of cap cells, myoepithelial cells and body cells. However, aberrant transgenic endbuds are surrounded by an increased amount of periductal stroma that in many cases encompasses the entire endbud. These data suggest that Krct may play a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.