ReviewPhotosynthesis research2005
Glutathione homeostasis and redox-regulation by sulfhydryl groups.
Review in Photosynthesis research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 248 citations in OpenAlex.
- Haptoglobin Phenotypes Stratify Post-Exertional Cognitive Dysfunction Associated with Altered Cerebral Oxygenation and Metabolic Signatures in Long COVID.International journal of molecular sciences · 2026Observational
- A GLUTAMATE CYSTEINE LIGASE Gene StGSH1 Regulated by StERF10 Enhanced Glutathione Accumulation and Adaptation to Low Phosphorus Stress in Potato.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Microorganisms' perception, scavenging, and adaptation to reactive oxygen species signals in microbe-plant interactions.World journal of microbiology & biotechnology · 2025Review
- Iron Overload-Related Oxidative Stress Leads to Hyperphosphorylation and Altered Anion Exchanger 1 (Band 3) Function in Erythrocytes from Subjects with β-Thalassemia Minor.International journal of molecular sciences · 2025Article
- Anaerobic HgII reduction is driven by cellular HgII-thiol interactions.Access microbiology · 2025Article
- Thiol-based redox sensing regulates the yellow pigment and antioxidant accumulation and improves the nutritional quality of wheat grains (Frontiers in plant science · 2025Article
- Comparison of Tumour-Specific Phenotypes in Human Primary and Expandable Pancreatic Cancer Cell Lines.International journal of molecular sciences · 2023Article
- Comparison of Reactive Sites in 2(1Molecules (Basel, Switzerland) · 2023Article
- The Application of Sulfur Influences Microbiome of Soybean Rhizosphere and Nutrient-Mobilizing Bacteria in Andosol.Microorganisms · 2023Article
- An Approach to Evaluate Pb Tolerance and Its Removal Mechanisms byJournal of fungi (Basel, Switzerland) · 2023Article
- Transcriptome and Metabolome Reveal the Molecular Mechanism of Barley Genotypes Underlying the Response to Low Nitrogen and Resupply.International journal of molecular sciences · 2023Article
- Flipping Off and On the Redox Switch in the Microcirculation.Annual review of physiology · 2023Review
- Catalytic System for Aerobic Oxidation That Simultaneously Functions as Its Own Redox Buffer.Inorganic chemistry · 2023Article
- Glutathione contributes to plant defence against parasitic cyst nematodes.Molecular plant pathology · 2022Article
- Impact of Ferrous Sulfate on Thylakoidal Multiprotein Complexes, Metabolism and Defence ofPlants (Basel, Switzerland) · 2022Article
- Environmental and Production Aspects of Using Fertilizers Based on Waste Elemental Sulfur and Organic Materials.Materials (Basel, Switzerland) · 2022Article
- Antioxidant enzyme responses and metabolite functioning of Pisum sativum L. to sewage sludge in arid and semi-arid environments.Environmental science and pollution research international · 2022Article
- Roles of Exogenous α-Lipoic Acid and Cysteine in Mitigation of Drought Stress and Restoration of Grain Quality in Wheat.Plants (Basel, Switzerland) · 2021Article
- Differences in Acid Stress Response ofMicroorganisms · 2021Article
- The Arbuscular Mycorrhizal FungusCells · 2021Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Continuous control of metabolism and developmental processes is a key feature of live cells. Cysteine thiol residues of proteins are both exceptionally useful in terms of structural and regulatory aspects, but at the same time exceptionally vulnerable to oxidation. Conserved cysteines thus are highly important for the function of metabolic enzymes and for signaling processes underlying responses to environmental factors. The underlying mechanism for the central role of thiol-mediated redox control in cellular metabolism is the ability of the cysteine-thiols to reversibly change their redox state followed by changes of structural, catalytic or regulatory functions. The cellular glutathione/glutathione disulfide redox buffer is present in cells at millimolar concentrations and forms one major basis of redox homeostasis by which protein thiols can maintain their redox state or oxidized protein thiols can be reverted to their reduced state. Besides acting as redox buffer, glutathione also acts as an electron donor for both scavenging of reactive oxygen, e.g. from photosynthesis and respiration, and metabolic reactions such as reduction of hydroperoxides and lipidperoxides or sulfate assimilation. The central role of glutathione is further emphasized by its involvement in signaling processes and the crosstalk of redox signaling processes with other means of signaling including protein glutathionylation and control of transcription factors. The present review aims at highlighting the key functions of glutathione in thiol-mediated redox control and its interplay with other protein-thiol-based redox systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.