ArticleOncogene2006
CDX2 has tumorigenic potential in the human colon cancer cell lines LOVO and SW48.
Article in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- The Regulatory Role of Neuropeptide Gene Glucagon in Colorectal Cancer: A Comprehensive Bioinformatic Analysis.Disease markers · 2022Article
- Essential role of ALKBH5-mediated RNA demethylation modification in bile acid-induced gastric intestinal metaplasia.Molecular therapy. Nucleic acids · 2021Article
- Single-cell genetic analysis of clonal dynamics in colorectal adenomas indicates CDX2 gain as a predictor of recurrence.International journal of cancer · 2019Article
- PARP1 is required for preserving telomeric integrity but is dispensable for A-NHEJ.Oncotarget · 2018Article
- Human somatic cells deficient for RAD52 are impaired for viral integration and compromised for most aspects of homology-directed repair.DNA repair · 2017Article
- Immature myeloid progenitors promote disease progression in a mouse model of Barrett's-like metaplasia.Oncotarget · 2015Article
- Overexpression of caudal-related homeobox transcription factor 2 inhibits the growth of transplanted colorectal tumors in nude mice.Molecular medicine reports · 2015Article
- Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation.The EMBO journal · 2015Article
- Overexpression of CDX2 in gastric cancer cells promotes the development of multidrug resistance.American journal of cancer research · 2015Article
- Predictive gene signatures: molecular markers distinguishing colon adenomatous polyp and carcinoma.PloS one · 2014Article
- A novel CDX2 isoform regulates alternative splicing.PloS one · 2014Article
- Reversal of multidrug resistance in gastric cancer cells by CDX2 downregulation.World journal of gastroenterology · 2013Article
- Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction.Nucleic acids research · 2013Article
- CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling.The Journal of clinical investigation · 2013Article
- siRNA targeting of Cdx2 inhibits growth of human gastric cancer MGC-803 cells.World journal of gastroenterology · 2012Article
- Caudal homeobox protein Cdx-2 cooperates with Wnt pathway to regulate claudin-1 expression in colon cancer cells.PloS one · 2012Article
- AAV-mediated gene targeting methods for human cells.Nature protocols · 2011Article
- Efficient derivation of pluripotent stem cells from siRNA-mediated Cdx2-deficient mouse embryos.Stem cells and development · 2011Article
- Intestine-specific transcription factor Cdx2 induces E-cadherin function by enhancing the trafficking of E-cadherin to the cell membrane.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CDX2 is a Drosophila caudal-related homeobox transcription factor that is important for the establishment and maintenance of intestinal epithelial cells. CDX2 is a marker of colon cancer, with strong staining in up to 90% of colonic adenocarcinomas. CDX2 heterozygous-null mice develop colonic neoplasms, which have suggested that CDX2 is a tumor suppressor. However, CDX2 has not been reported to affect xenograft growth. Furthermore, CDX2 is rarely mutated in colon cancer, which has led to suggestions that it may play only a minor role as a tumor suppressor in colon cancer. To understand the functional contributions of CDX2 to colon cancer, we disrupted CDX2 in LOVO and SW48 human colon cancer cell lines by targeted homologous recombination. Consistent with the literature, disruption of CDX2 enhanced anchorage-dependent cell proliferation. However, homozygous loss of CDX2 led to significant inhibition of anchorage-independent growth in LOVO cells, and cell lethality in SW48 cells. Further analyses revealed that disruption of CDX2 led to anchorage-independent G1 to S growth arrest and anoikis. In vivo xenograft studies confirmed that disruption of CDX2 inhibited LOVO tumor growth. These data demonstrate that CDX2 mediates anchorage-independent growth and survival. Thus, CDX2 has tumorigenic potential in the human colon cancer cell lines LOVO and SW48.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.