ArticleProceedings of the National Academy of Sciences of the United States of America2005
Loss of dispensable genes is not adaptive in yeast.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Synthetic negative genome screen of the GPN-loop GTPase NPA3 in Saccharomyces cerevisiae.Current genetics · 2022Article
- An Alternative Molecular View of Evolution: How DNA was Altered over Geological Time.Molecules (Basel, Switzerland) · 2020Article
- Whole-Genome Analysis of Three Yeast Strains Used for Production of Sherry-Like Wines Revealed Genetic Traits Specific to Flor Yeasts.Frontiers in microbiology · 2018Article
- Development of a Comprehensive Genotype-to-Fitness Map of Adaptation-Driving Mutations in Yeast.Cell · 2016Article
- The fates of mutant lineages and the distribution of fitness effects of beneficial mutations in laboratory budding yeast populations.Genetics · 2014Article
- The reference genome sequence of Saccharomyces cerevisiae: then and now.G3 (Bethesda, Md.) · 2014Article
- Measuring competitive fitness in dynamic environments.The journal of physical chemistry. B · 2013Article
- The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast.Cell reports · 2012Article
- Virtual genomes in flux: an interplay of neutrality and adaptability explains genome expansion and streamlining.Genome biology and evolution · 2012Article
- Article
- Experimental genomics of fitness in yeast.Proceedings. Biological sciences · 2010Review
- Abundant indispensable redundancies in cellular metabolic networks.Genome biology and evolution · 2009Article
- The cost of gene expression underlies a fitness trade-off in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Adaptation, extinction and global change.Evolutionary applications · 2008Article
- The loss of adaptive plasticity during long periods of environmental stasis.The American naturalist · 2007Article
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2 authors.
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Abstract
A substantial share of genes identified in yeast can be deleted without visible phenotypic effects. Current debate concentrates on the possible roles of seemingly dispensable genes. The costs of maintaining unnecessary functions has attracted little attention. The hypothesis of antagonistic pleiotropy postulates that adaptations to different constituents of the environment are likely to interfere with each other, and therefore loss of unnecessary functions is potentially advantageous. We tested an entire collection of nonessential yeast gene deletions in a benign and nutritionally rich environment in which the number of dispensable genes was particularly high. We applied a series of competition experiments that could detect differences in relative fitness of approximately 0.005. No beneficial deletions were found, except perhaps for the deletion of about a dozen genes that slightly improved competitive ability; however, a functional explanation of the fitness advantage is lacking. The paucity of beneficial gene deletions is striking because genetic adaptations to laboratory conditions are regularly observed in yeast. However, it accords with the finding that the gene contents of four species of Saccharomyces are nearly identical, despite up to 20 million years of independent evolution and extensive DNA sequence divergence. Such extreme conservation of functions would be improbable if there were periods of selection promoting the loss of temporarily dispensable genes. The evident cohesion of the yeast genomes may be their evolved feature or an intrinsic property of complex genetic systems.
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