ArticleProceedings of the National Academy of Sciences of the United States of America2005
Retrograde signaling from the brain to the retina modulates the termination of the light response in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Parallel Synaptic Acetylcholine Signals Facilitate Large Monopolar Cell Repolarization and Modulate Visual Behavior inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Genetics of decayed sexual traits in a parasitoid wasp with endosymbiont-induced asexuality.Heredity · 2014Article
- Genetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity.Journal of neurogenetics · 2009Article
- Article
- Distinct roles for two histamine receptors (hclA and hclB) at the Drosophila photoreceptor synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Feedback network controls photoreceptor output at the layer of first visual synapses in Drosophila.The Journal of general physiology · 2006Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
A critical factor in visual function is the speed with which photoreceptors (PRs) return to the resting state when light intensity dims. Several elements subserve this process, many of which promote the termination of the phototransduction cascade. Although the known elements are intrinsic to PRs, we have found that prompt restoration to the resting state of the Drosophila electroretinogram can require effective communication between the retina and the underlying brain. The requirement is seen more dramatically with long than with short light pulses, distinguishing the phenomenon from gross disruption of the termination machinery. The speed of recovery is affected by mutations (in the Hdc and ort genes) that prevent PRs from transmitting visual information to the brain. It is also affected by manipulation (using either drugs like neostigmine or genetic tools to inactivate neurotransmitter release) of cholinergic signals that arise in the brain. Intracellular recordings support the hypothesis that PRs are the target of this communication. We infer that signaling from the retina to the optic lobe prompts a feedback signal to retinal PRs. Although the mechanism of this retrograde signaling remains to be discerned, the phenomenon establishes a previously unappreciated mode of control of the temporal responsiveness of a primary sensory neuron.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.