ArticleProceedings of the National Academy of Sciences of the United States of America2005
Global gene expression profiles reveal significant nuclear reprogramming by the blastocyst stage after cloning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Molecular and cellular programs underlying the development of bovine pre-implantation embryos.Reproduction, fertility, and development · 2023Article
- Pre-Implantation Bovine Embryo Evaluation-From Optics to Omics and Beyond.Animals : an open access journal from MDPI · 2023Review
- Genes associated with survival of female bovine blastocysts produced in vivo.Cell and tissue research · 2020Article
- Molecular fingerprint of female bovine embryos produced in vitro with high competence to establish and maintain pregnancy†.Biology of reproduction · 2020Article
- Article
- Improves the In Vitro Developmental Competence and Reprogramming Efficiency of Cloned Bovine Embryos by Additional Complimentary Cytoplasm.Cellular reprogramming · 2019Article
- Methylome Dynamics of Bovine Gametes andFrontiers in genetics · 2019Article
- Production of hypoallergenic milk from DNA-free beta-lactoglobulin (BLG) gene knockout cow using zinc-finger nucleases mRNA.Scientific reports · 2018Article
- Gene expression of bovine embryos developing at the air-liquid interface on oviductal epithelial cells (ALI-BOEC).Reproductive biology and endocrinology : RB&E · 2017Article
- Large-scale production of recombinant human lactoferrin from high-expression, marker-free transgenic cloned cows.Scientific reports · 2017Article
- Combined positive effect of oocyte extracts and brilliant cresyl blue stained recipient cytoplasts on epigenetic reprogramming and gene expression in buffalo nuclear transfer embryos.Cytotechnology · 2017Article
- Profile of Harris A. Lewin.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Massive dysregulation of genes involved in cell signaling and placental development in cloned cattle conceptus and maternal endometrium.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Effects of High Hydrostatic Pressure on Expression Profiles of In Vitro Produced Vitrified Bovine Blastocysts.Scientific reports · 2016Article
- Article
- Transcriptional profiles of bovine in vivo pre-implantation development.BMC genomics · 2014Article
- OMICS: Current and future perspectives in reproductive medicine and technology.Journal of human reproductive sciences · 2014Review
- Massive deregulation of miRNAs from nuclear reprogramming errors during trophoblast differentiation for placentogenesis in cloned pregnancy.BMC genomics · 2014Article
- Genome-wide analysis of DNA methylation in bovine placentas.BMC genomics · 2014Article
- Article
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10 authors.
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Abstract
Nuclear transfer (NT) has potential applications in agriculture and biomedicine, but the technology is hindered by low efficiency. Global gene expression analysis of clones is important for the comprehensive study of nuclear reprogramming. Here, we compared global gene expression profiles of individual bovine NT blastocysts with their somatic donor cells and fertilized control embryos using cDNA microarray technology. The NT embryos' gene expression profiles were drastically different from those of their donor cells and closely resembled those of the naturally fertilized embryos. Our findings demonstrate that the NT embryos have undergone significant nuclear reprogramming by the blastocyst stage; however, problems may occur during redifferentiation for tissue genesis and organogenesis, and small reprogramming errors may be magnified downstream in development.
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