ArticleMolecular and cellular biology2005
Rasgrf1 imprinting is regulated by a CTCF-dependent methylation-sensitive enhancer blocker.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 99 citations in OpenAlex.
- Review
- CTCF shapes chromatin structure and gene expression in health and disease.EMBO reports · 2022Review
- DNA Methylation Analysis of Imprinted Genes in the Cortex and Hippocampus of Cross-Fostered Mice Selectively Bred for Increased Voluntary Wheel-Running.Behavior genetics · 2022Article
- Deletion ofInternational journal of molecular sciences · 2022Article
- A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus.Developmental cell · 2021Article
- Ras GEF Mouse Models for the Analysis of Ras Biology and Signaling.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Epigenetic Inactivation of the Tumor SuppressorCancers · 2020Article
- Role of genomic imprinting in mammalian development.Journal of biosciences · 2020Review
- Genetic enhancement of Ras-ERK pathway does not aggravate L-DOPA-induced dyskinesia in mice but prevents the decrease induced by lovastatin.Scientific reports · 2018Article
- Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic mice.Epigenetics & chromatin · 2018Article
- Asymmetric DNA methylation of CpG dyads is a feature of secondary DMRs associated with theEpigenetics & chromatin · 2017Article
- Imprinted DNA methylation reconstituted at a non-imprinted locus.Epigenetics & chromatin · 2016Article
- TRIM28 Controls Genomic Imprinting through Distinct Mechanisms during and after Early Genome-wide Reprogramming.Cell reports · 2015Article
- Novel CTCF binding at a site in exon1A of BCL6 is associated with active histone marks and a transcriptionally active locus.Oncogene · 2015Article
- What does genetics tell us about imprinting and the placenta connection?Cellular and molecular life sciences : CMLS · 2015Review
- Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease.Oncogene · 2014Review
- Article
- The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs).Age (Dordrecht, Netherlands) · 2013Article
- Identification of imprinting regulators at the Meg3 differentially methylated region.Genomics · 2012Article
- RasGRF1 regulates proliferation and metastatic behavior of human alveolar rhabdomyosarcomas.International journal of oncology · 2012Article
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Imprinted methylation of the paternal Rasgrf1 allele in mice occurs at a differentially methylated domain (DMD) 30 kbp 5' of the promoter. A repeated sequence 3' of the DMD regulates imprinted methylation, which is required for imprinted expression. Here we identify the mechanism by which methylation controls imprinting. The DMD is an enhancer blocker that binds CTCF in a methylation-sensitive manner. CTCF bound to the unmethylated maternal allele silences expression. CTCF binding to the paternal allele is prevented by repeat-mediated methylation, allowing expression. Optimal in vitro enhancer-blocking activity requires CTCF binding sites. The enhancer blocker can be bypassed in vivo and imprinting abolished by placing an extra enhancer proximal to the promoter. Together, the repeats and the DMD constitute a binary switch that regulates Rasgrf1 imprinting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.