ArticleMolecular and cellular biology2005
The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 56 citations in OpenAlex.
- The BEN domain protein LIN-14 coordinates neuromuscular positioning during epidermal maturation.iScience · 2025Article
- Structural and physiological functions ofHeliyon · 2024Review
- Neural Circuit Remodeling: Mechanistic Insights from Invertebrates.Journal of developmental biology · 2024Review
- Glia in Invertebrate Models: Insights from Caenorhabditis elegans.Advances in neurobiology · 2024Review
- Orthologs of the Caenorhabditis elegans heterochronic genes have divergent functions in Caenorhabditis briggsae.Genetics · 2023Article
- Unanticipated broad phylogeny of BEN DNA-binding domains revealed by structural homology searches.Current biology : CB · 2023Article
- The heterochronic LIN-14 protein is a BEN domain transcription factor.Current biology : CB · 2023Article
- Article
- DamID identifies targets of CEH-60/PBX that are associated with neuron development and muscle structure in Caenorhabditis elegans.PloS one · 2020Article
- Neuronal function of the mRNA decapping complex determines survival ofOpen biology · 2017Article
- Stage-Specific Timing of the microRNA Regulation of lin-28 by the Heterochronic Gene lin-14 in Caenorhabditis elegans.Genetics · 2017Article
- Alzheimer-related protein APL-1 modulates lifespan through heterochronic gene regulation in Caenorhabditis elegans.Aging cell · 2016Article
- Reconstruction of the insulin-like signalling pathway of Haemonchus contortus.Parasites & vectors · 2016Article
- Modulation of C. elegans touch sensitivity is integrated at multiple levels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology.PLoS genetics · 2014Article
- Transcriptional regulation of gene expression in C. elegans.WormBook : the online review of C. elegans biology · 2013Review
- Ageing and the small, non-coding RNA world.Ageing research reviews · 2013Review
- Contributions of mRNA abundance, ribosome loading, and post- or peri-translational effects to temporal repression of C. elegans heterochronic miRNA targets.Genome research · 2012Article
- The lin-4 microRNA targets the LIN-14 transcription factor to inhibit netrin-mediated axon attraction.Science signaling · 2012Article
- Sensitive and precise quantification of insulin-like mRNA expression in Caenorhabditis elegans.PloS one · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
A temporal gradient of the novel nuclear protein LIN-14 specifies the timing and sequence of stage-specific developmental events in Caenorhabditis elegans. The profound effects of lin-14 mutations on worm development suggest that LIN-14 directly or indirectly regulates stage-specific gene expression. We show that LIN-14 can associate with chromatin in vivo and has in vitro DNA binding activity. A bacterially expressed C-terminal domain of LIN-14 was used to select DNA sequences that contain a putative consensus binding site from a pool of randomized double-stranded oligonucleotides. To identify candidates for genes directly regulated by lin-14, we employed DNA microarray hybridization to compare the mRNA abundance of C. elegans genes in wild-type animals to that in mutants with reduced or elevated lin-14 activity. Five of the candidate LIN-14 target genes identified by microarrays, including the insulin/insulin-like growth factor family gene ins-33, contain putative LIN-14 consensus sites in their upstream DNA sequences. Genetic analysis indicates that the developmental regulation of ins-33 mRNA involves the stage-specific repression of ins-33 transcription by LIN-14 via sequence-specific DNA binding. These results reinforce the conclusion that lin-14 encodes a novel class of transcription factor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.