ArticleMolecular and cellular biology2005
Human TopBP1 ensures genome integrity during normal S phase.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 70 citations in OpenAlex.
- ATR and TopBP1 oppose to control dormant origin activity and global replication dynamics, providing a first defense against replication stress.Nucleic acids research · 2026Article
- Article
- Active DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation.Nature communications · 2022Article
- The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis.Current biology : CB · 2020Article
- Dicer prevents genome instability in response to replication stress.Oncotarget · 2019Article
- The ATR-Activation Domain of TopBP1 Is Required for the Suppression of Origin Firing during the S Phase.International journal of molecular sciences · 2018Article
- SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- TopBP1 contributes to the chemoresistance in non-small cell lung cancer through upregulation of p53.Drug design, development and therapy · 2016Article
- TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells.The Journal of cell biology · 2015Article
- TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis.PLoS genetics · 2015Article
- High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation.Nucleic acids research · 2015Article
- Levels of the E2 interacting protein TopBP1 modulate papillomavirus maintenance stage replication.Virology · 2015Article
- Article
- TopBP1 controls BLM protein level to maintain genome stability.Molecular cell · 2013Article
- An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.PLoS genetics · 2013Article
- DNA damage tolerance: a double-edged sword guarding the genome.Translational cancer research · 2013Article
- Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.PloS one · 2013Article
- An interaction between human papillomavirus 16 E2 and TopBP1 is required for optimum viral DNA replication and episomal genome establishment.Journal of virology · 2012Article
- Expression of TopBP1 in hereditary breast cancer.Molecular biology reports · 2012Article
- Deficiency of H3K79 histone methyltransferase Dot1-like protein (DOT1L) inhibits cell proliferation.The Journal of biological chemistry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Cell cycle checkpoints are essential for maintaining genomic integrity. Human topoisomerase II binding protein 1 (TopBP1) shares sequence similarity with budding yeast Dpb11, fission yeast Rad4/Cut5, and Xenopus Cut5, all of which are required for DNA replication and cell cycle checkpoints. Indeed, we have shown that human TopBP1 participates in the activation of replication checkpoint and DNA damage checkpoints, following hydroxyurea treatment and ionizing radiation. In this study, we address the physiological function of TopBP1 in S phase by using small interfering RNA. In the absence of exogenous DNA damage, TopBP1 is recruited to replicating chromatin. However, TopBP1 does not appear to be essential for DNA replication. TopBP1-deficient cells have increased H2AX phosphorylation and ATM-Chk 2 activation, suggesting the accumulation of DNA double-strand breaks in the absence of TopBP1. This leads to formation of gaps and breaks at fragile sites, 4N accumulation, and aberrant cell division. We propose that the cellular function of TopBP1 is to monitor ongoing DNA replication. By ensuring proper DNA replication, TopBP1 plays a critical role in the maintenance of genomic stability during normal S phase as well as following genotoxic stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.