ArticleMolecular and cellular biology2005
Runx1 binds positive transcription elongation factor b and represses transcriptional elongation by RNA polymerase II: possible mechanism of CD4 silencing.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- CDK9 phosphorylates RUNX1 to promote megakaryocytic fate in megakaryocytic-erythroid progenitors.Blood · 2024Article
- Transitional cell states sculpt tissue topology during lung regeneration.Cell stem cell · 2023Article
- Short tandem repeats are important contributors to silencer elements in T cells.Nucleic acids research · 2023Article
- P-TEFb: The master regulator of transcription elongation.Molecular cell · 2023Review
- The regulation of transcription elongation in embryonic stem cells.Frontiers in cell and developmental biology · 2023Review
- Runx proteins and transcriptional mechanisms that govern memory CD8 T cell development.Immunological reviews · 2021Review
- Alprazolam Prompts HIV-1 Transcriptional Reactivation and Enhances CTL Response Through RUNX1 Inhibition and STAT5 Activation.Frontiers in neurology · 2021Article
- Different modes of enhancer-specific regulation by Runt and Even-skipped duringMolecular biology of the cell · 2017Article
- Runx1 repression by histone deacetylation is critical for Setbp1-induced mouse myeloid leukemia development.Leukemia · 2016Article
- LMO2 induces T-cell leukemia with epigenetic deregulation of CD4.Experimental hematology · 2014Article
- Article
- RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction.Cell reports · 2013Article
- The epigenetic landscape of lineage choice: lessons from the heritability of CD4 and CD8 expression.Current topics in microbiology and immunology · 2012Review
- Article
- H3K4 tri-methylation provides an epigenetic signature of active enhancers.The EMBO journal · 2011Article
- A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.Molecular and cellular biology · 2010Article
- Progranulin (granulin/epithelin precursor) and its constituent granulin repeats repress transcription from cellular promoters.Journal of cellular physiology · 2010Article
- Megakaryocytic programming by a transcriptional regulatory loop: A circle connecting RUNX1, GATA-1, and P-TEFb.Journal of cellular biochemistry · 2009Review
- Defining the chromatin signature of inducible genes in T cells.Genome biology · 2009Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Runx1 binds the silencer and represses CD4 transcription in immature thymocytes. In this study, we found that Runx1 inhibits P-TEFb, which contains CycT1, CycT2, or CycK and Cdk9 and stimulates transcriptional elongation by RNA polymerase II (RNAPII) in eukaryotic cells. Indeed, its inhibitory domain, spanning positions 371 to 411, not only bound CycT1 but was required for silencing CD4 transcription in vivo. Our chromatin immunoprecipitation assays revealed that Runx1 inhibits the elongation but not initiation of transcription and that RNAPII is engaged at the CD4 promoter but is unable to elongate in CD4(-) CD8(+) thymoma cells. These results suggest that active repression by Runx1 occurs by blocking the elongation by RNAPII, which may contribute to CD4 silencing during T-cell development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.