ArticleThe American journal of pathology2005
Oral and nasal sensitization promote distinct immune responses and lung reactivity in a mouse model of peanut allergy.
Article in The American journal of pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- A murine model of peanut-allergic asthma.Frontiers in allergy · 2024Article
- Differential diagnostics of food allergy as based on provocation tests and laboratory diagnostic assays.Postepy dermatologii i alergologii · 2023Review
- Development and evaluation of mouse anti-Ara h 1 and Ara h 3 IgE monoclonal antibodies for advancing peanut allergy research.MethodsX · 2023Article
- Reactivity of nasal cavity mucosa in the nasal cow's milk allergen provocation test.Postepy dermatologii i alergologii · 2023Article
- The conjunctival allergen provocation test and the nasal allergen provocation test as specific alternatives to the oral food challenge.Postepy dermatologii i alergologii · 2022Review
- In utero exposure to genistein decreased intranasal house dust mite-induced respiratory allergy in middle-aged male B6C3F1 offspring.Toxicology letters · 2020Article
- Review
- Intestinal Epithelial Cells Regulate Gut Eotaxin Responses and Severity of Allergy.Frontiers in immunology · 2018Article
- LPS promotes Th2 dependent sensitisation leading to anaphylaxis in a Pru p 3 mouse model.Scientific reports · 2017Article
- In Utero exposure to genistein enhanced intranasal house dust mite allergen-induced respiratory sensitization in young adult B6C3F1 mice.Toxicology letters · 2016Article
- IKKβ in intestinal epithelial cells regulates allergen-specific IgA and allergic inflammation at distant mucosal sites.Mucosal immunology · 2014Article
- Article
- Article
- Article
- Use of animal models to investigate major allergens associated with food allergy.Journal of allergy · 2013Article
- An NF-κB-independent and Erk1/2-dependent mechanism controls CXCL8/IL-8 responses of airway epithelial cells to cadmium.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- Induction of allergic responses to peanut allergen in sheep.PloS one · 2012Article
- Contributions of edema factor and protective antigen to the induction of protective immunity by Bacillus anthracis edema toxin as an intranasal adjuvant.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- B cells are involved in the modulation of pathogenic gut immune response in food-allergic enteropathy.Clinical and experimental immunology · 2008Article
- Th1 and Th2 cells are required for both eosinophil- and neutrophil-associated airway inflammatory responses in mice.Biochemical and biophysical research communications · 2007Article
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Authors and funding
7 authors.
Funding
Abstract
Despite structural and functional differences between the initial sites of contact with allergens in the gastrointestinal and nasal tracts, few animal models have examined the influence of the mucosal routes of sensitization on host reactivity to food or environmental antigens. We compared the oral and nasal routes of peanut sensitization for the development of a mouse model of allergy. Mice were sensitized by administration of peanut proteins in the presence of cholera toxin as adjuvant. Antibody and cytokine responses were characterized, as well as airway reactivity to nasal challenge with peanut or unrelated antigens. Oral sensitization promoted higher levels of IgE, but lower IgG responses, than nasal sensitization. Both orally and nasally sensitized mice experienced airway hyperreactivity on nasal peanut challenge. The peanut challenge also induced lung eosinophilia and type 2 helper T-cell-type cytokines in orally sensitized mice. In contrast, peanut challenge in nasally sensitized mice promoted neutrophilia and higher levels of lung MAC-1(+) I-A(b low) cells and inflammatory cytokines. In addition, nasal but not oral, sensitization promoted lung inflammatory responses to unrelated antigens. In summary, both oral and nasal peanut sensitization prime mice for airway hyperreactivity, but the initial mucosal route of sensitization influences the nature of lung inflammatory responses to peanut and unrelated allergens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.