ArticleThe American journal of pathology2005
Cytoplasmic YY1 is associated with increased smooth muscle-specific gene expression: implications for neonatal pulmonary hypertension.
Article in The American journal of pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits.Scientific reports · 2021Pooled it
- Yin Yang 1: Function, Mechanisms, and Glia.Neurochemical research · 2025Review
- MultiCapsNet: A General Framework for Data Integration and Interpretable Classification.Frontiers in genetics · 2021Article
- PEBP1/RKIP behavior: a mirror of actin-membrane organization.Cellular and molecular life sciences : CMLS · 2020Article
- Molecular Studies on Pregnancy with Mouse Models.Current opinion in physiology · 2020Article
- miR-1-5p targets TGF-βR1 and is suppressed in the hypertrophying hearts of rats with pulmonary arterial hypertension.PloS one · 2020Article
- Conserved RNA binding activity of a Yin-Yang 1 homologue in the ova of the purple sea urchin Strongylocentrotus purpuratus.Scientific reports · 2018Article
- Tropomyosin isoforms have specific effects on the transcriptome of undifferentiated and differentiated B35 neuroblastoma cells.FEBS open bio · 2018Article
- miR-322-5p targets IGF-1 and is suppressed in the heart of rats with pulmonary hypertension.FEBS open bio · 2018Article
- miR-422a suppresses SMAD4 protein expression and promotes resistance to muscle loss.Journal of cachexia, sarcopenia and muscle · 2018Article
- Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo.Journal of cachexia, sarcopenia and muscle · 2016Article
- FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy.FEBS open bio · 2015Article
- Mechanisms of nuclear actin in chromatin-remodeling complexes.Trends in cell biology · 2014Review
- Transcriptional regulation and nuclear reprogramming: roles of nuclear actin and actin-binding proteins.Cellular and molecular life sciences : CMLS · 2013Review
- Nuclear actin and myosins at a glance.Journal of cell science · 2012Review
- Nuclear actin and myosins: life without filaments.Nature cell biology · 2011Review
- Yin yang 1 is a novel regulator of pulmonary fibrosis.American journal of respiratory and critical care medicine · 2011Article
- NF-E2-related factor 2, a key inducer of antioxidant defenses, negatively regulates the CFTR transcription.Cellular and molecular life sciences : CMLS · 2010Article
- Perfusion of veins at arterial pressure increases the expression of KLF5 and cell cycle genes in smooth muscle cells.Biochemical and biophysical research communications · 2010Article
- Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression.The FEBS journal · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immediately after birth the adluminal vascular SMCs of the pulmonary elastic arteries undergo transient actin cytoskeletal remodeling as well as cellular de-differentiation and proliferation. Vascular smooth muscle phenotype is regulated by serum response factor, which is itself regulated in part by the negative regulator YY1. We therefore studied the subcellular localization of YY1 in arteries of normal newborn piglets and piglets affected by neonatal pulmonary hypertension. We found that YY1 localization changed during development and that expression of gamma-smooth muscle actin correlated with expression of cytoplasmic rather than nuclear YY1. Analysis of the regulation of YY1 localization in vitro demonstrated that polymerized gamma-actin sequestered EGFP-YY1 in the cytoplasm and that YY1 activation of c-myc promoter activity was inhibited by LIM kinase, which increases actin polymerization. Consistent with these data siRNA-mediated down-regulation of YY1 in C2C12 cells increased SM22-alpha expression and inhibited cell proliferation. Thus, actin polymerization controls subcellular YY1 localization, which contributes to vascular SMC proliferation and differentiation in normal pulmonary artery development. In the absence of actin depolymerization, YY1 does not relocate to the nucleus, and this lack of relocation may contribute to the pathobiology of pulmonary hypertension.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.